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Review
. 2025 Jun;480(6):3521-3533.
doi: 10.1007/s11010-025-05219-w. Epub 2025 Feb 8.

Current understanding of PEAK family members in regulation of cellular signaling pathways and cancer therapy

Mana Alavi  1 , Raheleh Roudi  2 , Alberto D'Angelo  3 , Navid Sobhani  4 , Fatemeh Safari  5
Affiliations
Review

Current understanding of PEAK family members in regulation of cellular signaling pathways and cancer therapy

Mana Alavi et al. Mol Cell Biochem. 2025 Jun.

Abstract

Cancer evades therapy by multiple mechanisms, leading to uncontrolled cell growth and metastasis. Targeted therapies have shown promise in treating cancer by focusing on pathways within cancer cells. The PEAK family, comprising PEAK1 (SgK269), PEAK2 (SgK223/Pragmin), and the latest addition, PEAK3 (C19orf35), plays a crucial role in modulating cellular processes. Dysregulation and hyperactivity of these proteins, through overexpression or mutations, are associated with a wide range of cancers. This review delves into the different roles of the PEAK family members in regulating cell signaling pathways and highlights their potential in cancer therapy.

Keywords: Cancer therapy; Cell signaling pathways; PEAK3; SgK223; SgK269.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

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