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Multicenter Study
. 2025 Feb 8;20(1):61.
doi: 10.1186/s13023-025-03559-w.

Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden

Cristina Bulai Livideanu  1 , Jérémy Gottlieb  2 , Denis Jullien  3 , Thierry Passeron  4 , Sophie Vildy  5 , Emmanuel Delaporte  6 , Carle Paul  2   7 , Julien Chollet  8 , Marie Najean  8 , Denis San  8 , Charles Taieb  9 , Bénédicte Charles  10 , Emmanuel Mahe  11 , Pierre-André Becherel  12 , Laurent Misery  13   14
Affiliations
Multicenter Study

Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden

Cristina Bulai Livideanu et al. Orphanet J Rare Dis. .

Abstract

The objective of this study was to assess the demographic characteristics and impact on quality of life (QoL) of patients with PPG in France through a multicentre study. The results of the study are as follows: The PRO [PUSH-D, PHQ-9 et GAD-7] revealed that more than half of the patients exhibited a significant impact on their quality of life. High scores for fatigue, stress, skin and joint pain were reported, with 65% of patients at risk of mild to severe depression. The clinical burden was also assessed. A total of 48.8% of patients were hospitalised, while 39% took sick leave. This study is the first to assess the PUSH-D, PHQ-9 and GAD-7 scores in patients with PPG, which highlighted a significant clinical burden and negative impact on their daily lives.

Keywords: Burden; Generalized Pustular Psoriasis; Quality of life; Stigmatization.

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Conflict of interest statement

Declarations. Consent for publication: Prior to including individual data in this manuscript, consent for publication was obtained from all individuals whose data were included. This consent was obtained irrespective of the form in which the data would be presented. Disclosure: The authors meet criteria for authorship as recommended by the International Committee of Medical Journal Editors (ICMJE). The authors did not receive payment related to the development of the Letter to the Editor. Boehringer Ingelheim was given the opportunity to review the manuscript for medical and scientific accuracy as well as intellectual property considerations. Conflict of interest: Julien CHOLLET, Marie NAJEAN, and Denis SAN are employees of Boehringer Ingelheim France. Charles TAIEB was remunerated for the management of this study. The other co-authors received no remuneration in connection with this study. Ethical aspects: This project has received a favorable opinion from the Comité de Protection des Personnes Est III [ID-RCB 2022-A01749-34].

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