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. 1985 Feb 1;37(3):371-7.
doi: 10.1016/0049-3848(85)90066-0.

The effects of post-heparin plasma lipases on anti-Xa clotting activity

S P Williams, T W Barrowcliffe

The effects of post-heparin plasma lipases on anti-Xa clotting activity

S P Williams et al. Thromb Res. .

Abstract

The effects of hepatic triglyceride lipase (HTGL) and lipoprotein lipase (LPL) on the anti-Xa clotting activity of plasma were studied. LPL had no effect, but HTGL enhanced anti-Xa activity. This enhancement was shown to be due to a time-dependent action of HTGL on lipoproteins. These results could explain the increases in anti-Xa clotting activity previously observed after injection of heparin analogues, SSHA and SP54, which are potent releasers of lipase enzymes.

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