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. 2024 Dec;16(Suppl 4):S3607-S3609.
doi: 10.4103/jpbs.jpbs_1104_24. Epub 2024 Oct 30.

Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study

Saloni Verma  1 , Annuroopa Mahapatra  2 , Kavita Gupta  3 , Harisha Dewan  4 , Minu Raju  5 , D Anupama Prasad  6
Affiliations

Assessment of the Antibacterial Properties and Cytocompatibility of Implant Coatings Incorporating Antimicrobial Agents: An In vitro Study

Saloni Verma et al. J Pharm Bioallied Sci. 2024 Dec.

Abstract

Objective: This study evaluates the antibacterial efficacy and cytocompatibility of titanium implants coated with silver, chitosan, and antibiotics.

Materials and methods: Antibacterial properties were tested using inhibition zones against S. aureus, E. coli, and P. aeruginosa. The cytocompatibility was assessed through cell viability, adhesion, and proliferation by using human osteoblast-like cells (MG-63). Statistical analysis was performed using ANOVA and Tukey's HSD test.

Results: Antibiotics showed the highest antibacterial activity. Silver reduced cell viability, adhesion, and proliferation, while chitosan balanced antibacterial efficacy and biocompatibility. Time-dependent viability assays indicated consistent reduction for silver-treated cells.

Conclusion: Silver, chitosan, and antibiotics are effective against implant-related pathogens, but their cytocompatibility varies.

Keywords: Antibacterial efficacy; antibiotics; antimicrobial coatings; dental implants.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Graph 1
Graph 1
Antibacterial activity of coatings against bacterial strains
Graph 2
Graph 2
Time-dependent cell viability at 24, 48 and 72 hours
See this image and copyright information in PMC

References

    1. Alghamdi HS, Jansen JA. The development and future of dental implants. Dent Mater J. 2020;39:167–72. - PubMed
    1. Akshaya S, Rowlo PK, Dukle A, Nathanael AJ. Antibacterial coatings for titanium implants: Recent trends and future perspectives. Antibiotics. 2022;11:1719. - PMC - PubMed
    1. Zhang J, Gao M, Gao W, Yang P, Meng F, Liu Q, et al. Functional Silver nanoparticles as broad-spectrum antimicrobial agents. N J Chem. 2022;46:16387–93.
    1. Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M. Broad-spectrum bioactivities of silver nanoparticles: The emerging trends and future prospects. Appl Microbiol Biotechnol. 2014;98:1951–61. - PMC - PubMed
    1. Shimabukuro M. Antibacterial property and biocompatibility of silver, copper, and zinc in titanium dioxide layers incorporated by one-step micro-arc oxidation: A review. Antibiotics. 2020;9:716. - PMC - PubMed

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