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Review
. 2025 Feb 7:13:tkae052.
doi: 10.1093/burnst/tkae052. eCollection 2025.

Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity

Kang Huang  1   2 , Bobin Mi  1   2 , Yuan Xiong  1   2 , Zicai Fu  1   2 , Wenyun Zhou  1   2 , Wanjun Liu  1   2 , Guohui Liu  1   2 , Guandong Dai  1   2
Affiliations
Review

Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity

Kang Huang et al. Burns Trauma. .

Abstract

Diabetes mellitus, a pervasive chronic metabolic disorder, is often associated with complications such as impaired wound healing. Various factors, most notably vascular deficiency, govern the wound repair process in diabetic patients, significantly impeding diabetic wound healing; therefore, angiogenesis and its role in diabetic wound repair have emerged as important areas of research. This review aims to delve into the mechanisms of angiogenesis, the effects of diabetes on angiogenesis, and the association between angiogenesis and diabetic wound repair. This will ultimately offer valuable guidance regarding the ideal timing of diabetic wound treatment in a clinical setting.

Keywords: Angiogenesis; Diabetes mellitus; Diabetic foot ulcers; Diabetic wound; Timing of treatment.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Mechanisms of angiogenesis during wound healing. VEGFR vascular endothelial growth factor receptors, PDGFR platelet-derived growth factor receptors. Figure created with BioRender.com
Figure 2
Figure 2
Endothelial cellular dysfunction. O2− Superoxide anion, ONOO− peroxynitrite, BH2 dihydrobiopterin, BH4 tetrahydrobiopterin. Figure created with BioRender.com
Figure 3
Figure 3
Inflammatory signaling pathways. IFN-γ interferon-gamma, LPS lipopolysaccharide. Figure created with BioRender.com
Figure 4
Figure 4
Balance of angiogenesis promoting factor/angiogenesis inhibiting factor. Figure created with BioRender.com
Figure 5
Figure 5
Balance of MMPs/TIMPs. Figure created with BioRender.com
See this image and copyright information in PMC

References

    1. Collaborators, GBDD . Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021. Lancet 2023;402:203–34. 10.1016/S0140-6736(23)01301-6. - DOI - PMC - PubMed
    1. Burgess JL, Wyant WA, Abdo Abujamra B, Kirsner RS, Jozic I. Diabetic Wound-Healing Science, Vol. 57. Medicina (Kaunas), 2021. 10.3390/medicina57101072. - DOI - PMC - PubMed
    1. Armstrong, DG, Tan, TW, Boulton, AJM, Bus SA. Diabetic foot ulcers: a review. JAMA 2023;330:62–75. 10.1001/jama.2023.10578. - DOI - PMC - PubMed
    1. Rodrigues, M, Kosaric, N, Bonham, CA, Gurtner GC. Wound healing: a cellular perspective. Physiol Rev 2019;99:665–706. 10.1152/physrev.00067.2017. - DOI - PMC - PubMed
    1. Wang Z, Zhao F, Xu C, Zhang Q, Ren H, Huang X. et al. Metabolic reprogramming in skin wound healing. Burns Trauma 2024;12:tkad047. 10.1093/burnst/tkad047. - DOI - PMC - PubMed

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