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. 2025 Apr 1;26(4):e549-e551.
doi: 10.1097/PCC.0000000000003706. Epub 2025 Feb 11.

Digesting a Slice of the SANDWICH Trial and Its Effect on a Bronchiolitis Subpopulation

Jeremy M Loberger  1 , Kristina A Betters  2
Affiliations

Digesting a Slice of the SANDWICH Trial and Its Effect on a Bronchiolitis Subpopulation

Jeremy M Loberger et al. Pediatr Crit Care Med. .
No abstract available

Keywords: airway extubation; bronchiolitis; mechanical ventilation; patient-centered care; pediatrics; workload.

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Conflict of interest statement

Dr. Betters’ institution received funding from the National Heart, Lung, and Blood Institute (1R61HL151951-01). Dr. Loberger has disclosed that he does not have any potential conflicts of interest.

References

    1. Mitting RB, McDowell C, Blackwood B, et al.: Sedation and ventilator weaning bundle and time to extubation in infants with bronchiolitis: Secondary analysis of the Sedation AND Weaning in Children (SANDWICH) trial. Pediatr Crit Care Med. 2025; 26:e423–e431
    1. Blackwood B, Tume LN, Morris KP, et al.; SANDWICH Collaborators: Effect of a sedation and ventilator liberation protocol vs usual care on duration of invasive mechanical ventilation in pediatric intensive care units: A randomized clinical trial. JAMA. 2021; 326:401–410
    1. Curley MA, Wypij D, Watson RS, et al.; RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network: Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: A randomized clinical trial. JAMA. 2015; 313:379–389
    1. Smith HAB, Gangopadhyay M, Goben CM, et al.: Delirium and benzodiazepines associated with prolonged ICU stay in critically ill infants and young children. Crit Care Med. 2017; 45:1427–1435
    1. Linssen RS, Teirlinck AC, van Boven M, et al.: Increasing burden of viral bronchiolitis in the pediatric intensive care unit; an observational study. J Crit Care. 2022; 68:165–168

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