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. 2025 Jul;62(7):1183-1194.
doi: 10.1080/02770903.2025.2466182. Epub 2025 Feb 16.

Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry

Zeynep Celebi Sozener  1   2 , Ipek Kıvılcım Oguzulgen  3 , Funda Seher Ozalp Ates  4 , Ayse Baccioglu  5 , Serap Argun Barıs  6 , Dane Ediger  7 , Fatma Esra Gunaydın  8 , Can Sevinc  9 , Ummuhan Seker  10 , Bilge Yılmaz Kara  11 , Sengul Beyaz  2   11 , Dilsad Mungan  1 , Omur Aydin  1 , Derya Gokmen  12 , Gozde Koycu Buhari  13 , Bilun Gemicioglu  14 , Ismet Bulut  15 , Cihan Orcen  16 , Secil Kepil Ozdemir  17 , Metin Keren  18 , Ebru Damadoglu  19 , Tugce Yakut  20 , Ayse Fusun Kalpaklioglu  5 , Sumeyra Alan Yalim  5 , Insu Yilmaz  20 , Ilkay Koca Kalkan  13 , Mehmet Atilla Uysal  21 , Elif Yelda Ozgun Niksarlioglu  21 , Ali Fuat Kalyoncu  18 , Gul Karakaya  18 , Muge Erbay  22 , Sibel Nayci  23 , Fatma Merve Tepetam  15 , Asli Akkor Gelincik  11 , Hulya Dirol  24 , Ozlem Goksel  25 , Selen Karaoglanoglu  26 , Ferda Oner Erkekol  27   28 , Sacide Rana Isik  29 , Fusun Yildiz  6   30 , Yasemin Yavuz  1 , Dilek Karadogan  10 , Nurgul Bozkurt  24 , Ilknur Basyigit  6 , Elif Yilmazel Ucar  31 , Tuba Erdogan  32 , Mehmet Polatli  33 , Murat Turk  20   34 , Leyla Pur  35 , Zeynep Yegin Katran  15 , Yonca Sekibag  14 , Enes Furkan Aykac  14 , Ozcan Gul  1 , Ali Cengiz  1 , Bulent Akkurt  17 , Seyma Ozden  15 , Semra Demir  11 , Derya Unal  11 , Ayse Feyza Aslan  11 , Ali Can  11 , Reyhan Gumusburun  25 , Gulhan Bogatekin  25 , Hatice Serpil Akten  25 , Sinem Inan  25 , Munevver Erdinc  36 , Aliye Candan Ogus  24 , Murat Kavas  15 , Demet Polat Yulug  37 , Mehmet Erdem Cakmak  18 , Saltuk Bugra Kaya  18 , Gulistan Alpagat  5 , Eylem Sercan Ozgur  23 , Oguz Uzun  38 , Sule Tas Gulen  33 , Gulseren Pekbak  7 , Deniz Kizilirmak  39 , Yavuz Havlucu  39 , Halil Donmez  40 , Bahar Arslan  20 , Gulden Pacaci Cetin  20 , Sadan Soyyigit  27 , Gulden Pasaoglu Karakis  41 , Adile Berna Dursun  40   42 , Resat Kendirlinan  43 , Ayse Bilge Ozturk  44 , Gokcen Omeroglu Simsek  8 , Oznur Abadoglu  45 , Pamir Cerci  46 , Taskin Yucel  47 , Irfan Yorulmaz  48 , Zahide Ciler Tezcaner  48 , Emel Cadalli Tatar  49 , Ahmet Emre Suslu  47   50 , Serdar Ozer  47 , Engin Dursun  51 , Arzu Yorgancioglu  39 , Gulfem Elif Celik  1
Affiliations

Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry

Zeynep Celebi Sozener et al. J Asthma. 2025 Jul.

Abstract

Objective: The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma.

Methods: This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared.

Results: The obesity rate in TAAR was 32.2% (n = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%.

Conclusions: A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control.

Keywords: Asthma; control; obesity; phenotype; severe asthma.

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