Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Feb 3;8(2):e2459698.
doi: 10.1001/jamanetworkopen.2024.59698.

HPV E6 and E7 mRNA Test for the Detection of High-Grade Cervical Lesions

Awoke Derbie  1   2 , Melanie Maier  3 , Bereket Amare  1 , Eyaya Misgan  1 , Endalkachew Nibret  4 , Fantahun Biadglegne  1   5 , Uwe G Liebert  3 , Tsion Zewdu Minas  2   6 , Muluken Agage Yenesew  1 , Dabere Nigatu  1 , Tesfaye B Mersha  7 , Daniel A Enquobahrie  8 , Yimtubezinash Woldeamanuel  2   9 , Tamrat Abebe  9
Affiliations

HPV E6 and E7 mRNA Test for the Detection of High-Grade Cervical Lesions

Awoke Derbie et al. JAMA Netw Open. .
No abstract available

Plain language summary

This cross-sectional study examines whether human papillomavirus (HPV) messenger RNA (mRNA)–based testing can identify women with high-risk abnormal cervical lesions..

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None reported.

References

    1. Leto Md, Santos Júnior GF, Porro AM, Tomimori J. Human papillomavirus infection: etiopathogenesis, molecular biology and clinical manifestations. An Bras Dermatol. 2011;86(2):306-317. doi: 10.1590/S0365-05962011000200014 - DOI - PubMed
    1. Duvlis S, Popovska-Jankovic K, Arsova ZS, Memeti S, Popeska Z, Plaseska-Karanfilska D. HPV E6/E7 mRNA versus HPV DNA biomarker in cervical cancer screening of a group of Macedonian women. J Med Virol. 2015;87(9):1578-1586. doi: 10.1002/jmv.24199 - DOI - PubMed
    1. Zhang SK, Guo Z, Wang P, et al. The potential benefits of HPV E6/E7 mRNA test in cervical cancer screening in China. Front Oncol. 2020;10:533253. doi: 10.3389/fonc.2020.533253 - DOI - PMC - PubMed
    1. Fontecha N, Basaras M, Hernáez S, Andía D, Cisterna R. Assessment of human papillomavirus E6/E7 oncogene expression as cervical disease biomarker. BMC Cancer. 2016;16(1):852. doi: 10.1186/s12885-016-2885-x - DOI - PMC - PubMed
    1. Derbie A, Mekonnen D, Woldeamanuel Y, Van Ostade X, Abebe T. HPV E6/E7 mRNA test for the detection of high grade cervical intraepithelial neoplasia (CIN2+): a systematic review. Infect Agent Cancer. 2020;15:9-9. doi: 10.1186/s13027-020-0278-x - DOI - PMC - PubMed