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. 2025 Feb 3;8(2):e2459361.
doi: 10.1001/jamanetworkopen.2024.59361.

Accelerated Intermittent Theta-Burst Stimulation for Treatment-Resistant Bipolar Depression: A Randomized Clinical Trial

Lawrence G Appelbaum  1 , Hadley Daniels  1 , Liam Lochhead  1 , Bianca Bacio  1 , Robin Cash  2 , Cory R Weissman  1 , Jordan N Kohn  1 , Itay Hadas  1 , Zafiris J Daskalakis  1
Affiliations

Accelerated Intermittent Theta-Burst Stimulation for Treatment-Resistant Bipolar Depression: A Randomized Clinical Trial

Lawrence G Appelbaum et al. JAMA Netw Open. .
No abstract available

Plain language summary

This randomized clinical trial evaluates the effect of accelerated intermittent theta-burst stimulation, compared with sham stimulation, on depression severity in individuals with treatment-resistant bipolar depression.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Weissman reported receiving grants from The Milken Institute during the conduct of the study and grants from the National Institutes of Health, Wellcome Leap Inc, UCSD Sanford Institute for Empathy and Compassion, and Brain & Behavior Research Foundation outside the submitted work. Dr Daskalakis reported receiving grants from Brainsway Inc and nonfinancial support from Magventure Inc as well as serving on the scientific advisory board for Brainsway Inc during the conduct of the study. No other disclosures were reported.

Figures

Figure.
Figure.. Raw Montgomery-Åsberg Depression Rating Scale (MADRS) Scores and Change in Scores From Baseline
TMS indicates transcranial magnetic stimulation.
See this image and copyright information in PMC

References

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