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Comparative Study
. 2025 Feb 11;20(2):e0318462.
doi: 10.1371/journal.pone.0318462. eCollection 2025.

Comparative analysis of VMAT plans on Halcyon and infinity for lung cancer radiotherapy

Affiliations
Comparative Study

Comparative analysis of VMAT plans on Halcyon and infinity for lung cancer radiotherapy

Kainan Shao et al. PLoS One. .

Abstract

Objective The dosimetric characteristics and treatment efficiency of VMAT plans using two linear accelerator platforms, Halcyon and Infinity, in conventional radiotherapy for non-small cell lung cancer (NSCLC) are compared to provide data for selecting clinical equipment. The study also explores potential confounding factors that may influence treatment outcomes. Methods This retrospective cohort study aims to compare the dosimetric characteristics and treatment efficiency of VMAT plans delivered using Halcyon and Infinity linear accelerator platforms in patients with NSCLC. A retrospective analysis was performed on 60 NSCLC patients receiving conventional fractionated radiotherapy with VMAT plans developed for both Halcyon and Infinity. These plans were optimized with RayStation 9A with identical dose constraints and optimization parameters. The groups were compared in terms of target dose coverage, normal tissue sparing, plan complexity, and treatment efficiency. The dosimetric parameters included D98%, D2%, and Dmean for both the CTV and PTV and dose distributions for organs at risk (OARs), including the heart, lungs, and spinal cord. Logistic regression was performed to account for potential confounding factors, such as PTV volume, tumor stage, and tumor location. Results The VMAT plans of both platforms met the clinical dosimetric requirements. Halcyon showed superior protection of normal tissues in low-dose areas (e.g., Lungs V5Gy and Heart V30Gy), whereas Infinity excelled in controlling hot spots and achieving rapid dose fall-off at the target margins. Furthermore, Halcyon has fewer plan monitoring units and lower complexity than Infinity and reduced treatment time by 24.0%. Logistic regression analysis revealed that PTV volume was a significant predictor for dose metric differences, while tumor stage and tumor location had variable effects depending on the dose metric, highlighting the need to account for these factors in clinical comparisons. Overall, there was no significant difference in target dose coverage or uniformity between the platforms; each demonstrated specific strengths in protecting different OARs and in treatment execution efficiency. Conclusion Halcyon and Infinity offer distinct advantages in radiotherapy for NSCLC. Halcyon provides better protection of normal tissues and performance in low-dose regions, whereas Infinity offers greater treatment efficiency and superior control in high-dose regions. The study also highlights that PTV volume is an important factor influencing dosimetric outcomes. In choosing optimal radiotherapy equipment in clinical practice, the study results suggest that treatment planning should leverage the unique technical features of different accelerators to achieve the best individualized outcomes. Future studies should increase the sample size and employ prospective research designs to confirm the clinical relevance of these findings.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Histogram of tumor CTV and PTV volumes (side by side). The histogram illustrates the distribution of Clinical Target Volume (CTV) and Planning Target Volume (PTV) in 60 patients. The x-axis represents the volume in cubic centimeters (cm3), while the y-axis indicates the number of patients. This side-by-side comparison highlights the distribution differences between CTV and PTV across the patient cohort.
Fig 2
Fig 2. Statistical analysis results for the target dose metrics. The Halcyon and Infinity systems had similar performance in target dose coverage.
Fig 3
Fig 3. Dose analysis results for the lungs, heart, and spinal cord as the organs at risk.
Fig 4
Fig 4. Dose volume results for the lungs and heart as the organs at risk.
Fig 5
Fig 5. Mean DVH curves for the lungs and heart for 60 patients.

References

    1. Rodrigues G, Lock M, D’Souza D, Yu E, Van Dyk J. Prediction of radiation pneumonitis by dose - volume histogram parameters in lung cancer–a systematic review. Radiother Oncol 2004;71(2):127–38. doi: 10.1016/j.radonc.2004.02.015 - DOI - PubMed
    1. Graham MV, Purdy JA, Emami B, Harms W, Bosch W, Lockett MA, et al.. Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 1999;45(2):323–9. doi: 10.1016/s0360-3016(99)00183-2 - DOI - PubMed
    1. Tsujino K, Hirota S, Endo M, Obayashi K, Kotani Y, Satouchi M, et al.. Predictive value of dose-volume histogram parameters for predicting radiation pneumonitis after concurrent chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys 2003;55(1):110–5. doi: 10.1016/s0360-3016(02)03807-5 - DOI - PubMed
    1. Piotrowski T, Matecka-Nowak M, Milecki P. Prediction of radiation pneumonitis: dose-volume histogram analysis in 62 patients with non-small cell lung cancer after three-dimensional conformal radiotherapy. Neoplasma. 2005;52(1):56–62. - PubMed
    1. Hernando ML, Marks LB, Bentel GC, Zhou SM, Hollis D, Das SK, et al.. Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer. Int J Radiat Oncol Biol Phys 2001;51(3):650–9. doi: 10.1016/s0360-3016(01)01685-6 - DOI - PubMed

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