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Clinical Trial
. 2025 Mar;70(3):1034-1042.
doi: 10.1007/s10620-025-08908-0. Epub 2025 Feb 11.

Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication with Radiofrequency Ablation

Robert S Bresalier  1 , Nicholas J Shaheen  2 , Mike Hernandez  3 , Navtej Buttar  4 , Norman Marcon  5 , Sachin Wani  6 , Raman Muthusamy  7 , Gary Falk  8 , Tamara Tipps Johnson  9 , Peiying Yan  10 , Xiaofang Huo  11 , Tawana A Castille  12 , Gary Della'Zanna  13 , Ellen Richmond  13 , J Jack Lee  3 , Powel Brown  12 , Rhonda Souza  14
Affiliations
Clinical Trial

Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication with Radiofrequency Ablation

Robert S Bresalier et al. Dig Dis Sci. 2025 Mar.

Abstract

Objectives/methods: Placebo-controlled phase II study evaluated aspirin's effect on CDX2 mRNA and prostanoid production in native and neosquamous epithelium after successful radiofrequency ablation (RFA) in Barrett's esophagus.

Results: At 12 months TXB2, PGF2α, PGD2, PGE2, PGE1, and α13PGE2 increased in native squamous but not neosquamous epithelium in individuals randomized to placebo. Aspirin use significantly reduced CDX2 mRNA in native squamous epithelium, and was associated with decreases in PGE1, PGE2 and 13PGE2 in neosquamous epithelium.

Conclusions: After RFA, native squamous and neosquamous epithelium exhibit different molecular markers and responses to aspirin suggesting that different sources of squamous progenitors contribute to esophageal re-epithelization.

Keywords: Barrett’s esophagus; CDX2; Chemoprevention; Eicosanoids; Radiofrequency ablation.

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Conflict of interest statement

Declarations. Conflicts of interest: The authors declare no competing interests.

References

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