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. 2025 May;117(5):1182-1184.
doi: 10.1002/cpt.3600. Epub 2025 Feb 11.

Optimal Drug, Optimal Dose, or Both in the Pharmacological Treatment of Neonatal Opioid Withdrawal Syndrome?

Affiliations

Optimal Drug, Optimal Dose, or Both in the Pharmacological Treatment of Neonatal Opioid Withdrawal Syndrome?

Walter K Kraft. Clin Pharmacol Ther. 2025 May.
No abstract available

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Conflict of interest statement

The author declared no competing interests for this work.

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References

    1. Bada, H.S. et al. Clonidine as monotherapy for neonatal opioid withdrawal syndrome: a randomized trial. Pediatrics 154, e2023065610 (2024). - PMC - PubMed
    1. Gullickson, C. , Kuhle, S. & Campbell‐Yeo, M. Comparison of outcomes between morphine and concomitant morphine and clonidine treatments for neonatal abstinence syndrome. Acta Paediatr. 108, 271–274 (2019). - PubMed
    1. Eudy‐Byrne, R. et al. Pharmacometric dose optimization of buprenorphine in neonatal opioid withdrawal syndrome. Clin. Transl. Sci. 14, 2171–2183 (2021). - PMC - PubMed
    1. Tang, F. , Ng, C.M. , Horn, J. , Bada, H.S. , & Leggas, M. Pharmacokinetic modeling and model‐based hypothesis generation for dose optimization of clonidine in neonates with neonatal opioid withdrawal syndrome. Clin Pharmacol Ther. 117, 1254–1263 (2025). - PMC - PubMed
    1. Xie, H.G. , Cao, Y.J. , Gauda, E.B. , Agthe, A.G. , Hendrix, C.W. & Lee, H. Clonidine clearance matures rapidly during the early postnatal period: a population pharmacokinetic analysis in newborns with neonatal abstinence syndrome. J. Clin. Pharmacol. 51, 502–511 (2011). - PubMed

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