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. 2025 Feb 11;58(2):273-275.
doi: 10.1016/j.immuni.2025.01.014. Epub 2025 Feb 11.

Nerve-racking worms

Yisi Lu  1 , Ruaidhrí Jackson  2
Affiliations

Nerve-racking worms

Yisi Lu et al. Immunity. .

Abstract

The enteric nervous system is a key regulator of inflammation, crosstalking directly with the immune system at the mucosal surfaces of the gastrointestinal tract. In this issue of Immunity, Wang and colleagues demonstrate that intrinsic enteric neurons (iENs) sense interleukin (IL)-13 to restrain group 2 innate lymphoid cell (ILC2) activity during helminth infection, uncovering a novel neuro-immune-regulatory circuit.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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