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Editorial
. 2025 Apr;36(4):295-297.
doi: 10.1016/j.tem.2025.01.006. Epub 2025 Feb 11.

Do weight loss interventions challenge the obesity paradox in heart failure?

Salva R Yurista  1 , Robert A Eder  2 , W Scott Butsch  3 , Ivan Luptak  4
Affiliations
Editorial

Do weight loss interventions challenge the obesity paradox in heart failure?

Salva R Yurista et al. Trends Endocrinol Metab. 2025 Apr.

Abstract

Cardiovascular disease (CVD) remains a significant global health concern, with obesity recognized as a prominent risk factor. The 'obesity paradox' (OP) suggests that obesity does not always lead to adverse outcomes, particularly in heart failure (HF). In this forum, we discuss the relevance of the OP in the current therapeutic landscape for cardiometabolic diseases.

Keywords: GLP-1RAs; bariatric surgery; heart failure; obesity paradox.

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Conflict of interest statement

Declaration of interests None declared by authors.

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