Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 Mar;27(3):302-5.
doi: 10.1128/AAC.27.3.302.

In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester

G S Kobayashi, J R Little, G Medoff
Comparative Study

In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester

G S Kobayashi et al. Antimicrob Agents Chemother. 1985 Mar.

Abstract

N-D-Ornithyl amphotericin B methyl ester (N-D-ornithyl AmE) has a lower toxicity for animals than does amphotericin B (AmB), and peak serum levels can be achieved that are fourfold higher than those obtained with an equivalent dose of AmB. However, N-D-ornithyl AmE has one-fourth the in vitro activity and between one-fifth and one-eighth the in vivo activity of AmB. N-D-ornithyl AmE and the corresponding lysyl derivative also lack the immunoadjuvant effects of AmB.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Antibiot (Tokyo). 1972 Apr;25(4):259-60 - PubMed
    1. Proc Soc Exp Biol Med. 1971 Nov;138(2):571-4 - PubMed
    1. J Natl Cancer Inst. 1973 Apr;50(4):1047-50 - PubMed
    1. Cancer Res. 1974 May;34(5):974-8 - PubMed
    1. J Infect Dis. 1976 Feb;133(2):168-74 - PubMed

Publication types

LinkOut - more resources