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Comparative Study
. 1985 Mar;27(3):302-5.
doi: 10.1128/AAC.27.3.302.

In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester

G S Kobayashi, J R Little, G Medoff
Comparative Study

In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester

G S Kobayashi et al. Antimicrob Agents Chemother. 1985 Mar.

Abstract

N-D-Ornithyl amphotericin B methyl ester (N-D-ornithyl AmE) has a lower toxicity for animals than does amphotericin B (AmB), and peak serum levels can be achieved that are fourfold higher than those obtained with an equivalent dose of AmB. However, N-D-ornithyl AmE has one-fourth the in vitro activity and between one-fifth and one-eighth the in vivo activity of AmB. N-D-ornithyl AmE and the corresponding lysyl derivative also lack the immunoadjuvant effects of AmB.

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