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Review
. 2025 Jan 29:12:1390951.
doi: 10.3389/fpubh.2024.1390951. eCollection 2024.

COVID-19 vaccination: challenges in the pediatric population

Alice Nicoleta Azoicai #  1 , Ingrith Miron #  1 , Ancuta Lupu #  1 , Monica Mihaela Alexoae #  1 , Iuliana Magdalena Starcea #  1 , Mirabela Alecsa #  1 , Vasile Valeriu Lupu #  1 , Ciprian Danielescu #  2 , Alin Horatiu Nedelcu #  2 , Delia Lidia Salaru #  2 , Felicia Dragan #  3 , Ileana Ioniuc #  1
Affiliations
Review

COVID-19 vaccination: challenges in the pediatric population

Alice Nicoleta Azoicai et al. Front Public Health. .

Abstract

Vaccination is considered to be one of the most effective means of protecting individuals and populations from the risks associated with exposure to various pathogens. The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affected people of all ages worldwide. In response, several pharmaceutical companies rapidly leveraged their resources to develop vaccines within a very short period of time, leading to the introduction of new, improved, and combination vaccines for community-wide immunization. This review aims to provide a summary of the available literature on the efficacy and safety of COVID-19 vaccines in the pediatric population ranging from 0 to 18 years. An analysis of recent published studies reveals that the majority of clinical trials have reported a sustained immune response following COVID-19 vaccination in children across various age groups worldwide. The majority of the authors highlighted the effectiveness and safety of immunization schedules in children and adolescents. The population-level efficacy of this vaccination remains to be determined, provided that the benefits outweigh the potential risks. Long-term side effects must still be monitored to enable the development of safer and more effective vaccines for future pandemics.

Keywords: COVID-19; SARS-CoV-2; children; efficacy; safety; vaccine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Organisation Mondiale de la Santé . Plan d’action mondial pour les vaccins 2011-2020. Edit OMS (2013). Available at: https://www3.paho.org/hq/dmdocuments/2013/SNF3501.pdf (Accessed August 18, 2023).
    1. Organistation Mondiale de la Sante . GIVS. La vaccination dans le monde: Vision et stratégie 2006-2015. Available at: https://apps.who.int/gb/ebwha/pdf_files/EB128/B128_9-fr.pdf (Accessed December 15, 2023).
    1. Plotkin S, Orenstein W, Offit P. Vaccines. London, UK: Saunders Elsevier; (2008).
    1. Gregg NM, ADT B. eds. Vaccinology. An essential guide. Hoboken, NJ: Edit Wiley Blackwell; (2015).
    1. Clark EC, Neumann S, Hopkins S, Kostopoulos A, Hagerman L, Dobbins M. Changes to public health surveillance methods due to the COVID-19 pandemic: scoping review. JMIR Public Health Surveill. (2024) 10:e49185. doi: 10.2196/49185 - DOI - PMC - PubMed

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