KEYNOTE-585: disappointing results for perioperative pembrolizumab in gastric cancer
- PMID: 39944585
- PMCID: PMC11811557
- DOI: 10.21037/tgh-24-57
KEYNOTE-585: disappointing results for perioperative pembrolizumab in gastric cancer
Keywords: Neoadjuvant chemotherapy; gastric cancer; pathologic complete response; pembrolizumab.
Conflict of interest statement
Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://tgh.amegroups.com/article/view/10.21037/tgh-24-57/coif). The author has no conflicts of interest to declare.
Comment on
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Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomised phase 3 study.Lancet Oncol. 2024 Feb;25(2):212-224. doi: 10.1016/S1470-2045(23)00541-7. Epub 2023 Dec 19. Lancet Oncol. 2024. PMID: 38134948 Clinical Trial.
References
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- Shitara K, Rha SY, Wyrwicz LS, et al. Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomised phase 3 study. Lancet Oncol 2024;25:212-24. 10.1016/S1470-2045(23)00541-7 - DOI - PubMed
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- Shitara K, Van Cutsem E, Bang YJ, et al. Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial. JAMA Oncol 2020;6:1571-80. 10.1001/jamaoncol.2020.3370 - DOI - PMC - PubMed
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- Janjigian YY, Shitara K, Moehler M, et al. First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial. Lancet 2021;398:27-40. 10.1016/S0140-6736(21)00797-2 - DOI - PMC - PubMed
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