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Review
. 2025 Jan 23:25:100366.
doi: 10.1016/j.eurox.2025.100366. eCollection 2025 Mar.

Management of menopausal hot flushes. Recommendations from the Spanish Menopause Society

M Fasero  1   2 , M Sanchez  3 , L Baquedano  4 , I Gippini  5 , D Fuentes  6 , C Navarro  7 , E Beltrán  8 , M Lilue  9 , I Porcel  10 , C Pingarrón  11 , M Herrero  12 , P Romero  13 , T Ortega  14 , E Carretero  14 , S Palacios  9 , N Mendoza  8 , P J Coronado  15
Affiliations
Review

Management of menopausal hot flushes. Recommendations from the Spanish Menopause Society

M Fasero et al. Eur J Obstet Gynecol Reprod Biol X. .

Abstract

This project aims to develop recommendations for treating vasomotor symptoms (VMS) based on the Cervantes short-form scale score (menopausal domain) using the best available evidence. A total of 166 studies were selected: 108 randomized controlled trials, 23 systematic reviews, 3 reviews, 3 meta-analyses, 11 case-control studies, 9 observational studies, and 12 transversal studies. To achieve this objective, a series of PICO (Patient, Intervention, Comparison, and Outcome) questions have been established for the treatment of VMS. We evaluate the quality of the scientific evidence and, with the findings, create a decision framework to treat hot flashes based on the Cervantes short-form scale score.

Keywords: Climacteric symptoms; Flushing; Hot flashes; Hot flushes; Menopausal symptoms; Menopause; Vasomotor symptoms, night sweats.

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Conflict of interest statement

Maria Fasero competing interest: Astellas Pharma, Shionogui, MSD, Organon, Atika Pharma, Dermofarm, Theramex. Mariella Lilue: Shionogi, Novonordisk. Iris Porcel: Theramex, gedeon Richter, Adamed. Carmen Pingarron: Astellas, Pfizer, MSD, Uriach, Shionogi, Arica, Organon, Exeltis, Theramex, NTDs, Faes, Meiji. Mercedes Herrero: Atlantia, Bayer, Bial, Dermofarm, Exeltis, Gedeon Richter, Ibérica, Kern Pharma, MSD, Ordesa, Organon, ProcareHealth, Sysmex, Shionogui, Ther amex y Zambón. Pablo Romero: Astellas, Shionogi, Procare. Maria Teresa Ortega: None declared. Maria Emilia Carretero: None declared. Nicolas Mendoza: Astellas Pharma, Shionogi. Santiago palacios: Arkochim, Bayer Healthcare, Exeltis, Theramex,Gedeon Richter, Novo Nordisk, Procare Health, Serelys, Mithra, Lacer, Sandoz. Pluvio Coronado: Exeltis, Gedeon Richter, Novo Nordisk, Procare Health, Lacer, Theramex; Atika Pharma.

Figures

Chartchart 1
Chartchart 1
FLOWCHART BIBLIOGRAPHIC REVIEW.
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