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. 2024 Nov 12:12:125267.
doi: 10.52965/001c.125267. eCollection 2024.

Prenatal Acetaminophen Exposure and its Associated Risk for Attention Deficit Hyperactivity Disorder

Noah J Spillers, Norris C Talbot, Patrick M Luther, Gianni H Ly, Caylin J Roberts, Shahab Ahmadzadeh, Sahar Shekoohi, Omar Viswanath, Alan D Kaye

Prenatal Acetaminophen Exposure and its Associated Risk for Attention Deficit Hyperactivity Disorder

Noah J Spillers et al. Health Psychol Res. .

Abstract

Acetaminophen is one of the most commonly used over-the-counter antipyretic and analgesic drugs on the market and has been relevant in the medical world for almost a hundred years. It has maintained an excellent reputation as a safe therapeutic in several types of patient profiles. However, the number of children diagnosed with neurodevelopmental disorders, namely ADHD, have been on the rise. Recent findings have indicated an association between in utero exposure to acetaminophen and an increased risk of developing neurodevelopmental disorders such as ADHD in offspring. The mechanism by which this potential side effect occurs is difficult to pinpoint. However, it is known that the metabolism of acetaminophen is known to cause oxidative stress, which has been shown to influence the developing fetus. This review highlights the epidemiological data indicating the correlation between prenatal acetaminophen exposure and ADHD and discusses several proposed theories by which this phenomenon may occur. While there is not yet enough clinical evidence to prove that acetaminophen may cause ADHD, there is a strong enough correlation to indicate a warning to pregnant patients of the potential risks. The risks and benefits of treatment should be considered so that the patient may continue with the course of action with the most favorable outcome. This review was mainly based on manuscripts pulled from Google Scholar and PubMed. The purpose of this literature review is to assist clinicians to better understand lesser-known risks in acetaminophen usage in pregnant patients.

Keywords: ADHD; Acetaminophen; adverse effects; attention-deficit/hyperactivity disorder; epidemiology; oxidative stress.

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References

    1. Paracetamol: mechanism of action, applications and safety concern. Jóźwiak-Bebenista M., Nowak J. Z. 2014Acta Pol Pharm. 71(1):11–23. - PubMed
    1. Recent Patterns of Medication Use in the Ambulatory Adult Population of the United StatesThe Slone Survey. Kaufman D. W., Kelly J. P., Rosenberg L., Anderson T. E., Mitchell A. A. 2002JAMA. 287(3):337–344. doi: 10.1001/jama.287.3.337. https://doi.org/10.1001/jama.287.3.337 - DOI - DOI - PubMed
    1. Over-the-Counter Medications in Pregnancy. Servey J., Chang J. 2014Am Fam Physician. 90(8):548–555. - PubMed
    1. The safety of pediatric use of paracetamol (acetaminophen): a narrative review of direct and indirect evidence. Patel E., Jones J. P., III, Bono-Lunn D.., et al. 2022Minerva Pediatr. 74(6):774–788. doi: 10.23736/S2724-5276.22.06932-4. https://doi.org/10.23736/S2724-5276.22.06932-4 - DOI - DOI - PubMed
    1. An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. Teleanu D. M., Niculescu A. G., Lungu I. I.., et al. 2022Int J Mol Sci. 23(11):5938. doi: 10.3390/ijms23115938. https://doi.org/10.3390/ijms23115938 - DOI - DOI - PMC - PubMed

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