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. 2025 Aug 1;110(8):1849-1853.
doi: 10.3324/haematol.2024.285788. Epub 2025 Feb 13.

Changes in asparaginase exposure and toxicity profiles in obese pediatric acute lymphoblastic leukemia patients

John C Panetta  1 , Emily Ashcraft  2 , Sima Jeha  3 , Ching-Hon Pui  3 , Hiroto Inaba  3 , Seth E Karol  3 , Cheng Cheng  2 , Hope D Swanson  1
Affiliations

Changes in asparaginase exposure and toxicity profiles in obese pediatric acute lymphoblastic leukemia patients

John C Panetta et al. Haematologica. .
No abstract available

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References

    1. Gupta S, Wang C, Raetz EA, et al. Impact of asparaginase discontinuation on outcome in childhood acute lymphoblastic leukemia: a report from the Children’s Oncology Group. J Clin Oncol. 2020;38(17):1897-1905. - PMC - PubMed
    1. Denton CC, Rawlins YA, Oberley MJ, Bhojwani D, Orgel E. Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens. Pediatr Blood Cancer. 2018;65(3):e26891. - PMC - PubMed
    1. Christ TN, Stock W, Knoebel RW. Incidence of asparaginaserelated hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen. J Oncol Pharm Pract. 2018;24(4):299-308. - PubMed
    1. Buhtoiarov IN, Zembillas AS. Excessive toxicities of pegylated asparaginase in pediatric acute lymphoblastic leukemia patients with high body surface area: a call for action. Pediatr Blood Cancer. 2021;68(3):e28743. - PubMed
    1. Liu Y, Panetta JC, Yang W, et al. Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment. Blood. 2020;136(25):2955-2958. - PMC - PubMed

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