Mineral Stress and Vascular Aging: Decoding the Epigenetic Connection to Slow the Clock

Qian Li¹, Lifang Ye^{1

2}, Jeffrey J Hsu^{1

3

4}

Affiliations

¹ Departments of Medicine (Q.L., L.Y., J.J.H.), University of California, Los Angeles.
² Department of Cardiovascular Medicine, Heart Center, Zhejiang Provincial People's Hospital, Hangzhou, China (L.Y.).
³ Bioengineering (J.J.H.), University of California, Los Angeles.
⁴ Veterans Affairs Greater Los Angeles Health Care System, CA (J.J.H.).

Editorial

Qian Li et al. Circ Res. 2025.

. 2025 Feb 14;136(4):400-402.

doi: 10.1161/CIRCRESAHA.125.326064. Epub 2025 Feb 13.

Qian Li¹, Lifang Ye^{1

2}, Jeffrey J Hsu^{1

3

4}

¹ Departments of Medicine (Q.L., L.Y., J.J.H.), University of California, Los Angeles.
² Department of Cardiovascular Medicine, Heart Center, Zhejiang Provincial People's Hospital, Hangzhou, China (L.Y.).
³ Bioengineering (J.J.H.), University of California, Los Angeles.
⁴ Veterans Affairs Greater Los Angeles Health Care System, CA (J.J.H.).

No abstract available

Keywords: Editorials; aging; cardiovascular diseases; epigenomics; risk factors; vascular calcification; vascular diseases.

Conflict of interest statement

None.

Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification.
Ho CY, Wu MY, Thammaphet J, Ahmad S, Ho C S J, Draganova L, Anderson G, Jonnalagadda US, Hayward R, Shroff R, Wen WTL, Verhulst A, Foo RS, Shanahan CM. Ho CY, et al. Circ Res. 2025 Feb 14;136(4):379-399. doi: 10.1161/CIRCRESAHA.124.325374. Epub 2025 Jan 22. Circ Res. 2025. PMID: 39840455 Free PMC article.