Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2025 Aug;49(15):4224-4237.
doi: 10.1007/s00266-025-04727-w. Epub 2025 Feb 13.

Safety of Using Tutoplast-Processed Fascia Lata in Rhinoplasty: A Systematic Review and Meta-Analysis

Khalid H Al-Sebeih #  1 , Ebraheem Albazee #  2 , Mahmoud A Alsakka  1
Affiliations
Meta-Analysis

Safety of Using Tutoplast-Processed Fascia Lata in Rhinoplasty: A Systematic Review and Meta-Analysis

Khalid H Al-Sebeih et al. Aesthetic Plast Surg. 2025 Aug.

Abstract

Objective: To evaluate the safety profile of using tutoplast-processed fascia lata (TPFL) as a graft material in patients undergoing both primary and revision rhinoplasty.

Methods: PubMed, CENTRAL, Scopus, Web of Science, and EMBASE were searched. Eligible studies were evaluated for bias using the National Institutes of Health (NIH) assessment tool for cohort studies. Our safety outcomes included the incidence of graft resorption, infection, graft displacement, dorsal irregularity, overcorrected dorsal augmentation, and revision rates. Data were pooled as event rate (%) with a 95% confidence interval (CI) using STATA software.

Results: Nine studies, comprising 827 patients, were included. Eight studies were evaluated with a low risk of bias, and one study had a moderate risk of bias. The pooled proportion analysis demonstrated a low graft resorption rate (event rate = 2.64%, 95% CI [0.69%, 5.62%]), infection rate (event rate = 0.30%, 95% CI [0.02%, 0.83%]), dorsal irregularity rate (event rate = 0.96%, 95% CI [0.09%, 2.51%]), graft displacement rate (event rate = 0.45%, 95% CI [0.07%, 1.12%]), overcorrected dorsal augmentation rate (event rate = 1.29%, 95% CI [0.39%, 2.65%]), and revision rate (event rate = 3.99%, 95% CI [1.82%, 6.90%]).

Conclusion: This meta-analysis of 827 patients demonstrated that TPFL has a favorable safety profile in both primary and revision rhinoplasty, with low complication and revision rates. TPFL, whether used alone or in combination with cartilage, is a viable graft option for dorsal augmentation and enhancing nasal dorsum contour.

Level of evidence i: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Keywords: Dorsal augmentation; Fascia lata; Processed fascia lata; Rhinoplasty; TPFL; Tutoplast.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: None. Ethical Approval: Not applicable. Human or Animal Rights: Not applicable. Informed Consent: Not applicable.

References

    1. Segreto F, Marianetti T, Iademarco A, et al. Mechanically fragmented cartilage grafts in rhinoplasty: an up-to-date systematic review. J Plast Reconstr Aesthet Surg. 2024;95(3):250–65. https://doi.org/10.1016/j.bjps.2024.05.036 . - DOI - PubMed
    1. Nikparto N, Yari A, Mehraban SH, et al. The current techniques in dorsal augmentation rhinoplasty: a comprehensive review. Maxillofac Plast Reconstr Surg. 2024;46:16. https://doi.org/10.1186/s40902-024-00418-9 . - DOI - PubMed - PMC
    1. Kim C-H, Park SC. Homologous tissue for dorsal augmentation. Facial Plast Surg Clin North Am. 2018;26(3):311–21. https://doi.org/10.1016/j.fsc.2018.03.005 . - DOI - PubMed
    1. Salzano G, Audino G, Dell’AversanaOrabona G, et al. Fresh frozen homologous rib cartilage: a narrative review of a new trend in rhinoplasty. J Clin Med. 2024;13(6):1715. https://doi.org/10.3390/jcm13061715 . - DOI - PubMed - PMC
    1. Al-Sebeih KH, Albazee E, Abu-Zaid A, Alsakka MA. Long-term safety and reliability of using Tutoplast-processed fascia lata to refine the nasal dorsum in primary and revision rhinoplasty. Aesthet Plast Surg. 2024;48(10):2651–62. https://doi.org/10.1007/s00266-024-03860-2 . - DOI

LinkOut - more resources