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. 2025 May 5;20(9):e202400955.
doi: 10.1002/cmdc.202400955. Epub 2025 Feb 25.

Synthesis and Bio-Evaluation of Quaternized Fused-β-Carbolines as Anti-MRSA Agents

Adilakshmi Vutla  1   2 , Deepanshi Saxena  3 , Rahul Maitra  3 , Sidharth Chopra  3   2 , Sanjay Batra  1
Affiliations

Synthesis and Bio-Evaluation of Quaternized Fused-β-Carbolines as Anti-MRSA Agents

Adilakshmi Vutla et al. ChemMedChem. .

Erratum in

Abstract

The drastic increase in the emergence of methicillin and vancomycin resistant S. aureus has resulted in almost negligible treatment options available to tackle these drug-resistant strains and therefore, search for newer antibiotics is essential. In this context, a new series of quaternized fused β-carbolines was synthesized and evaluated for its anti-bacterial potential. Several compounds from the series displayed potent anti-bacterial activity against Gram-positive bacteria including the drug-resistant strains with minimal cytotoxicity and promising bactericidal action.

Keywords: Antibacterial; Aza-heterocycle; Mannich reaction; S. aureus; β-carboline.

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References

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