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Comparative Study
. 1985 Apr;19(4):483-7.
doi: 10.1111/j.1365-2125.1985.tb02673.x.

Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians

M Jurima, T Inaba, D Kadar, W Kalow
Comparative Study

Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians

M Jurima et al. Br J Clin Pharmacol. 1985 Apr.

Abstract

The genetically controlled mephenytoin p(4')-hydroxylation capacity was determined in 118 Caucasians and 70 Orientals. After an oral dose of 50 or 100 mg of racemic mephenytoin, the amount of p(4')-hydroxymephenytoin in 24 h urine was measured by gas chromatography. Bimodal distribution was found with 9/70 (13%) Orientals and 5/118 (4%) Caucasians demonstrating deficient p(4')-hydroxylation. The statistically significant difference between Orientals and Caucasians (P less than 0.05) was accounted for by the high incidence of poor metabolizers among the Japanese subjects, 7/31 (23%). The frequency among Chinese subjects, 2/39 (5%), was similar to the frequency among Caucasians.

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