Broadening the Healthy Aging Paradigm: Inclusion of Gestation, Development, and Reproductive Health

Lan Yao^{1

2}, John Eikelboom^{3

4}, Andrew Macnab⁵, Zhuo Yu⁶, Yanhong Cao⁷, Wei Wei⁷, Shuqiu Sun⁷, Asma Khalil^{8

9}, William C Cho¹⁰, Farah Naz Qamar¹¹, Peter Kremsner^{12

13}, Miquel Oliu-Barton^{14

15}, Lishi Wang¹⁶, Ivan Sisa¹⁷, Florian Marks^{18

19

20

21}, Cong-Yi Wang²², J Carolyn Graff²³, Scott C Howard²⁴, Tianshu Gu²⁵, Marcello Maida²⁶, Edward V Prochownik^{27

28

29

30}, Tapfumanei Mashe^{31

32}, Alyce D Fly³³, Yang Hui^{34

35}, Andrea B Maier^{36

37

38}, Sami Aleya³⁹, Dianjun Sun⁷, Gang Wang⁴⁰, Evelyne Yehudit Bischof^{41

42

43}, Lotfi Aleya⁴⁴, Weikuan Gu^{2

45

46}

Affiliations

¹ College of Health Management, Harbin Medical University, Harbin, Heilongjiang 157 Baojian Road, Harbin, Heilongjiang, 150081, China.
² Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, TN, 38163, USA.
³ Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.
⁴ Department of Medicine, McMaster University, Hamilton, ON, Canada.
⁵ The Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, 7600, South Africa.
⁶ Heilongjiang Academy of Traditional Chinese Medicine, Sanfu Road 142, Xiangfang District, Harbin, 150040, China.
⁷ Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Key Laboratory of Etiologic Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health 23618104, 157 Baojian Road, Harbin, Heilongjiang, 150081, P. R. China.
⁸ Fetal Medicine Unit, St George's Hospital, St George's University of London, London, UK.
⁹ Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St. George's University of London, London, UK.
¹⁰ Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China.
¹¹ Department of Pediatrics and Child Health, Aga Khan University Hospital, National Stadium Rd, Karachi, Sindh, 74800, Pakistan.
¹² Institut für Tropenmedizin, Universität Tübingen, 72074, Tübingen, Germany.
¹³ Centre de Recherches Medicales de Lambaréné, Gabon.
¹⁴ Université Paris Dauphine - PSL, Pl. du Maréchal de Lattre de Tassigny, Paris, 75016, France.
¹⁵ Bruegel, rue de la Charité 33, Brussels, 1210, Belgium.
¹⁶ Department of Basic Medicine, Inner Mongolia Medical University, Jinshan Development Zone, Huhhot, China.
¹⁷ College of Health Sciences, Universidad San Francisco de Quito, Quito, 170901, Ecuador.
¹⁸ International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
¹⁹ Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK.
²⁰ Heidelberg Institute of Global Health, University of Heidelberg, Im Neuenheimer Feld 130/3, 69120, Heidelberg, Germany.
²¹ Madagascar Institute for Vaccine Research, University of Antananarivo, Antananarivo, 3HM2+QH7, Madagascar.
²² The Centre for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
²³ College of Nursing, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
²⁴ Resonance, Inc., 2298 Young Ave PMB 6 Memphis, Memphis, TN, 38104, USA.
²⁵ College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
²⁶ Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, 94100, Italy.
²⁷ Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA.
²⁸ Department of Microbiology and Molecular Genetics, UPMC, Pittsburgh, PA, 15261, USA.
²⁹ Hillman Cancer Center of UPMC, Pittsburgh, PA, 15232, USA.
³⁰ Pittsburgh Liver Research Center, UPMC, Pittsburgh, PA, 15261, USA.
³¹ One Health Office, Ministry of Health and Child Care, Harare, Zimbabwe.
³² World Health Organization, Harare, Zimbabwe.
³³ Department of Nutrition and Health Science, College of Health, Ball State University, Muncie, IN, 47306, USA.
³⁴ Department of Biochemistry and Molecular Biology, Harbin Medical University, 157 BaoJian Road Nangang Dist, Harbin, 150086, China.
³⁵ Basic Medical Institute of Heilongjiang Medical Science Academy, Harbin, China.
³⁶ Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Van der Boechorststraat 9, Amsterdam, 1081 BT, The Netherlands.
³⁷ Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
³⁸ NUS Academy for Healthy Longevity, @AgeSingapore, National University of Singapore, Singapore, Singapore.
³⁹ Faculty of Medecine, Université de Bourgogne Franche-Comté, Hauts-du-Chazal, Besançon, 25030, France.
⁴⁰ Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
⁴¹ State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
⁴² Shanghai University of Medicine and Health Sciences, Shanghai, China.
⁴³ Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Via S. Pansini, Naples, 580131, Italy.
⁴⁴ Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, Besançon Cedex, F-25030, France.
⁴⁵ The Lt. Col. Luke Weathers, Jr. VA Medical Center, Memphis, TN, 38163, USA.
⁴⁶ Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

PMID: 39950362
DOI: 10.1002/adbi.202400481

Broadening the Healthy Aging Paradigm: Inclusion of Gestation, Development, and Reproductive Health

Lan Yao et al. Adv Biol (Weinh). 2025 Apr.

. 2025 Apr;9(4):e2400481.

doi: 10.1002/adbi.202400481. Epub 2025 Feb 14.

Authors

Affiliations

¹ College of Health Management, Harbin Medical University, Harbin, Heilongjiang 157 Baojian Road, Harbin, Heilongjiang, 150081, China.
² Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Centre, Memphis, TN, 38163, USA.
³ Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.
⁴ Department of Medicine, McMaster University, Hamilton, ON, Canada.
⁵ The Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, 7600, South Africa.
⁶ Heilongjiang Academy of Traditional Chinese Medicine, Sanfu Road 142, Xiangfang District, Harbin, 150040, China.
⁷ Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Key Laboratory of Etiologic Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health 23618104, 157 Baojian Road, Harbin, Heilongjiang, 150081, P. R. China.
⁸ Fetal Medicine Unit, St George's Hospital, St George's University of London, London, UK.
⁹ Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St. George's University of London, London, UK.
¹⁰ Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China.
¹¹ Department of Pediatrics and Child Health, Aga Khan University Hospital, National Stadium Rd, Karachi, Sindh, 74800, Pakistan.
¹² Institut für Tropenmedizin, Universität Tübingen, 72074, Tübingen, Germany.
¹³ Centre de Recherches Medicales de Lambaréné, Gabon.
¹⁴ Université Paris Dauphine - PSL, Pl. du Maréchal de Lattre de Tassigny, Paris, 75016, France.
¹⁵ Bruegel, rue de la Charité 33, Brussels, 1210, Belgium.
¹⁶ Department of Basic Medicine, Inner Mongolia Medical University, Jinshan Development Zone, Huhhot, China.
¹⁷ College of Health Sciences, Universidad San Francisco de Quito, Quito, 170901, Ecuador.
¹⁸ International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
¹⁹ Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK.
²⁰ Heidelberg Institute of Global Health, University of Heidelberg, Im Neuenheimer Feld 130/3, 69120, Heidelberg, Germany.
²¹ Madagascar Institute for Vaccine Research, University of Antananarivo, Antananarivo, 3HM2+QH7, Madagascar.
²² The Centre for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
²³ College of Nursing, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
²⁴ Resonance, Inc., 2298 Young Ave PMB 6 Memphis, Memphis, TN, 38104, USA.
²⁵ College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
²⁶ Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, 94100, Italy.
²⁷ Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA.
²⁸ Department of Microbiology and Molecular Genetics, UPMC, Pittsburgh, PA, 15261, USA.
²⁹ Hillman Cancer Center of UPMC, Pittsburgh, PA, 15232, USA.
³⁰ Pittsburgh Liver Research Center, UPMC, Pittsburgh, PA, 15261, USA.
³¹ One Health Office, Ministry of Health and Child Care, Harare, Zimbabwe.
³² World Health Organization, Harare, Zimbabwe.
³³ Department of Nutrition and Health Science, College of Health, Ball State University, Muncie, IN, 47306, USA.
³⁴ Department of Biochemistry and Molecular Biology, Harbin Medical University, 157 BaoJian Road Nangang Dist, Harbin, 150086, China.
³⁵ Basic Medical Institute of Heilongjiang Medical Science Academy, Harbin, China.
³⁶ Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Van der Boechorststraat 9, Amsterdam, 1081 BT, The Netherlands.
³⁷ Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
³⁸ NUS Academy for Healthy Longevity, @AgeSingapore, National University of Singapore, Singapore, Singapore.
³⁹ Faculty of Medecine, Université de Bourgogne Franche-Comté, Hauts-du-Chazal, Besançon, 25030, France.
⁴⁰ Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
⁴¹ State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
⁴² Shanghai University of Medicine and Health Sciences, Shanghai, China.
⁴³ Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Via S. Pansini, Naples, 580131, Italy.
⁴⁴ Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, Besançon Cedex, F-25030, France.
⁴⁵ The Lt. Col. Luke Weathers, Jr. VA Medical Center, Memphis, TN, 38163, USA.
⁴⁶ Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

PMID: 39950362
DOI: 10.1002/adbi.202400481

Abstract

The prevailing focus of lifespan health research has predominantly centered on "healthy aging". This oversight may hinder the understanding of health across the lifespan, as disorders in earlier stages can substantially impact overall health and longevity. Aging, conceptually, begins at gestation. The trajectory of an individual's health is influenced from the earliest stages of life, where adverse conditions can set a foundation for lifelong health challenges. For example, suboptimal conditions during gestation leading to premature birth can predispose individuals to various health issues later in life. Additionally, precocious puberty defined as the onset of sexual maturity before eight years of age or early menopause-occurring before 50 years of age requires medical intervention and is indicative of atypical aging processes. To address these critical gaps in lifespan health research, the expansion of medical lexicons and research categorizations is advocated to include "healthy gestation," "healthy development," and "healthy reproduction" alongside "healthy aging." This broader terminology will enable a more comprehensive investigation of disorders at all life stages. An integrative approach underscores the interconnectedness of all life stages and the continuous nature of aging, advocating for a seamless continuum in health research and interventions from gestation through late adulthood.

Keywords: aging; development; gestation; lifespan; longevity; puberty; reproduction.

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Broadening the Healthy Aging Paradigm: Inclusion of Gestation, Development, and Reproductive Health

Affiliations

Broadening the Healthy Aging Paradigm: Inclusion of Gestation, Development, and Reproductive Health

Authors

Affiliations

Abstract

References

MeSH terms

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