Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger: A NOTION-2 substudy
- PMID: 39952377
- DOI: 10.1016/j.ahj.2025.02.003
Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger: A NOTION-2 substudy
Abstract
This NOTION-2 sub-study revealed distinct outcomes for transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in low surgical risk patients aged ≤ 70 years with a tricuspid or bicuspid aortic valve stenosis (AS). One year after intervention, the risk of death, stroke or rehospitalization in patients with tricuspid AS was similar after TAVR when compared to SAVR (absolute risk difference: -2.0%; 95% confidence interval (CI): -11.8% to 7.7%) Conversely, in patients with bicuspid AS, TAVR was associated with a significantly higher risk of adverse outcomes (absolute risk difference: 13.8%; 95% CI: 1.2% to 26.3%). These analyses are exploratory, but highlight the importance of tailoring the intervention to the patient's clinical risk profile, life expectancy, native aortic valve morphology and the anticipated risks associated with TAVR or SAVR.
Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Conflict of interest Savontaus, M. received honoaria from Medtronic, Boston Scientific and Edwards LifeSciences; Angerås, O. received honoraria from Medtronic, Abbott, Meril and support for attending meeting and travel from Meril, Abbott; Rück, A. received grants, consulting fees and participated in data safety monitoring board with Boston Scientific; Christiansen, E. received honoaraia from Meril; Predergast, B is in advisory Board Anteris, Trial Steering Committee Medtronic and Data Safety Monitoring Committee Valvosoft; Leon M has recieved grant from Edwards Lifesciences, Abbott Vascular and Medtronic, consultant fees from Foldax and Anteris, is in data saftemonitoring board with Medtronic, have leadership role in Heart Valve Collaboratory and stocks in Pi-Cardia; Søndergaard, L. is employee at Abbott; De Baclker, O. received consulting fees from Abott, Boston Scientific, Medtronic.
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