Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Feb 15;20(1):126.
doi: 10.1186/s13019-025-03372-3.

Clinical outcomes after surgical resection in asymptomatic and symptomatic children with congenital lung malformations

Rattapon Uppala  1   2 , Pongsakorn Udomdirekkul  1 , Sirapoom Niamsanit  1 , Leelawadee Techasatian  1   2 , Suchaorn Saengnipanthkul  1   2 , Phanthila Sitthikarnkha  3   4
Affiliations

Clinical outcomes after surgical resection in asymptomatic and symptomatic children with congenital lung malformations

Rattapon Uppala et al. J Cardiothorac Surg. .

Abstract

Purpose: Our study aims to evaluate the outcomes of children with congenital lung malformation (CLM) who have undergone surgical resection.

Methods: A retrospective analysis was conducted among children under 18 who were diagnosed with CLM and underwent surgery at Srinagarind Hospital, Khon Kaen University between January 2007 and December 2023. We collected data on surgical outcomes, including operative time, postoperative complications, and mortality rate.

Results: During our study period, a total of 38 children with CLM were undergone surgery. The median time for diagnosis was 9 months (IQR 1-33 months). Congenital pulmonary airway malformation was the most common diagnosis, affecting 26 children (68.4%). Of these, 25 children were operated on when they presented with symptoms, while 13 children were operated on even though they were asymptomatic. The median age at surgery was 12 months (IQR 3-32 months) for symptomatic children and 6 months (IQR 3-12 months) for asymptomatic children (P = 0.201). After the surgery, symptomatic children had a higher rate of postoperative complications than asymptomatic children, with 52% and 15.4%, respectively (P = 0.028). The median length of stay for symptomatic children was 17 days, compared to 11 days for asymptomatic children (P = 0.280).

Conclusions: Early surgery of CLM in asymptomatic children was associated with a lower rate of postoperative complications. Further studies are needed to investigate long-term complications.

Keywords: Children; Congenital lung malformation; Outcome; Surgery.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study protocol was approved by the human research ethics committee of Khon Kaen University (HE651065). The informed consent was waived as it was a retrospective observational study with no more than minimal risk. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of children diagnosed with congenital lung malformation (CLM) included in the study
Fig. 2
Fig. 2
The number of children diagnosed with congenital lung malformations (CLM) categorized by symptomatic and asymptomatic cases
See this image and copyright information in PMC

References

    1. Andrade CF, Ferreira HP da C, Fischer GB. Congenital lung malformations. J Bras Pneumol. 2011;37:259–71. - PubMed
    1. Chowdhury MM, Chakraborty S. Imaging of congenital lung malformations. Semin Pediatr Surg. 2015;24:168–75. - PubMed
    1. Annunziata F, Bush A, Borgia F, Raimondi F, Montella S, Poeta M, et al. Congenital lung malformations: unresolved issues and unanswered questions. Front Pediatr. 2019;7:239. - PMC - PubMed
    1. Baird R, Puligandla PS, Laberge J-M. Congenital lung malformations: informing best practice. Semin Pediatr Surg. 2014;23:270–7. - PubMed
    1. Stanton M, Njere I, Ade-Ajayi N, Patel S, Davenport M. Systematic review and meta-analysis of the postnatal management of congenital cystic lung lesions. J Pediatr Surg. 2009;44:1027–33. - PubMed

LinkOut - more resources