MEK Inhibition With Trametinib for the treatment of MAP2K1-Mutated Rosai-Dorfman-Destombes Disease Arising from the Nasopharynx in a Paediatric Patient

Affiliations

¹ Department of Paediatric Oncology, Southampton Children's Hospital, Southampton, UK.
² Department of ENT, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
³ Department of ENT, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
⁴ Department of Histopathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁵ Department of Radiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁶ Department of Paediatrics, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
⁷ Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Claire Cuerden et al. Pediatr Blood Cancer. 2025 May.

. 2025 May;72(5):e31595.

doi: 10.1002/pbc.31595. Epub 2025 Feb 16.

¹ Department of Paediatric Oncology, Southampton Children's Hospital, Southampton, UK.
² Department of ENT, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
³ Department of ENT, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
⁴ Department of Histopathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁵ Department of Radiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁶ Department of Paediatrics, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
⁷ Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

No abstract available

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