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Case Reports
. 2025 Jan 15;17(1):e77481.
doi: 10.7759/cureus.77481. eCollection 2025 Jan.

Dilated Cardiomyopathy and Hyperthyroidism: A Case Report and Literature Review

Oussama Elgharnati  1 , Ikram Damoune  1   2 , Abdelmajid Chraibi  1   2
Affiliations
Case Reports

Dilated Cardiomyopathy and Hyperthyroidism: A Case Report and Literature Review

Oussama Elgharnati et al. Cureus. .

Abstract

Dilated cardiomyopathy (DCM) is a rare but potentially reversible complication of hyperthyroidism, often resulting from severe thyrotoxicosis, leading to ventricular dilatation and reduced systolic function. A 45-year-old patient presented with progressive dyspnea and peripheral edema. Laboratory tests and imaging confirmed hyperthyroidism-induced DCM with a reduced ejection fraction (30%). Treatment with carbimazole and propranolol resulted in the normalization of thyroid function and cardiac recovery within three months. Hyperthyroidism can induce cardiac remodeling through genomic and non-genomic mechanisms of thyroid hormones, leading to reversible DCM. Early diagnosis and management are essential to avoid long-term complications, as delayed treatment may result in irreversible myocardial damage. This case highlights the need for multidisciplinary collaboration.

Keywords: dilated cardiomyopathy; heart failure; hyperthyroidism; reversibility; thyrotoxicosis.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Initial transthoracic echocardiography revealing dilated heart chambers with reduced ejection fraction (30%).
Figure 2
Figure 2. Initial chest X-ray showing cardiomegaly with increased overall dimensions of the heart.
Figure 3
Figure 3. Follow-up transthoracic echocardiography showing the normalization of cardiac dimensions (left ventricular end-diastolic diameter of 52 mm) and improved systolic function (ejection fraction of 60%) with no evidence of hypokinesis.
See this image and copyright information in PMC

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