Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 11:30:101506.
doi: 10.1016/j.artd.2024.101506. eCollection 2024 Dec.

Glucagon-Like Peptide-1 Receptor Agonist Use is Not Associated With Increased Complications After Total Knee Arthroplasty in Patients With Type-2 Diabetes

Kevin Y Heo  1 , Rahul K Goel  2 , Andrew Fuqua  1 , Jeffrey S Holmes  1 , Brian T Muffly  3 , Greg A Erens  1 , Jacob M Wilson  1 , Ajay Premkumar  1
Affiliations

Glucagon-Like Peptide-1 Receptor Agonist Use is Not Associated With Increased Complications After Total Knee Arthroplasty in Patients With Type-2 Diabetes

Kevin Y Heo et al. Arthroplast Today. .

Abstract

Background: Glucagon-like peptide-1 (GLP-1) agonists have emerged as a powerful diabetic treatment adjunct; however, its effects on outcomes following total knee arthroplasty (TKA) are not well known. The purpose of this study was to compare the risk of complications after TKA in patients with type-2 diabetes who were on GLP-1 agonists with those who were not.

Methods: In total, 34,696 type 2 diabetes patients undergoing primary TKA between 2016 and 2021 were retrospectively reviewed utilizing a large national database. Propensity score matching was employed to match patients on GLP-1 agonists to controls at a 1:1 ratio (n = 2388 each). Multivariable logistic regression was utilized to examine 90-day and 1-year TKA outcomes between cohorts.

Results: Controls had higher odds of extended hospital stays (≥3 days) (odds ratio 1.29, P < .001). However, surgical complication rates at 90-days including surgical site infection and prosthetic joint infection were not significantly different. Similarly, no differences were seen in medical complications. There were also no significant differences in rates of all-cause revision TKA and aseptic revision TKA at 1 year postoperatively.

Conclusions: This study found that GLP-1 agonist use was not associated with increased medical or surgical complication rates in patients with diabetes undergoing TKA and was associated with lower rates of extended hospital stays after surgery. Given the potential for increased glycemic control and weight loss in patients using GLP-1 agonists, more data are needed to delineate the potential role of GLP-1 agonists in preoperative optimization of patients with diabetes prior to joint arthroplasty to minimize postoperative complications.

Keywords: Complications; Diabetes; GLP-1 receptor agonist; Glucagon-like Peptide-1 receptor agonist; Total knee arthroplasty.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Propensity-score distribution in unmatched and matched datasets: cohort 1 – glucagon-like peptide (GLP)-1 agonist vs no GLP-1 agonist.
See this image and copyright information in PMC

References

    1. Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage. 2013;21:1145–1153. - PMC - PubMed
    1. Kurtz S., Ong K., Lau E., Mowat F., Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89:780–785. - PubMed
    1. Viganò R., Marega L., Breemans E., Miró R.L. A systematic literature review of the Profix in primary total knee arthroplasty. Acta Orthop Belg. 2012;78:55–60. - PubMed
    1. Sayah S.M., Karunaratne S., Beckenkamp P.R., Horsley M., Hancock M.J., Hunter D.J., et al. Clinical course of pain and function following total knee arthroplasty: a systematic review and meta-regression. J Arthroplasty. 2021;36:3993–4002.e37. - PubMed
    1. Yong T.M., Young E.C., Molloy I.B., Fisher B.M., Keeney B.J., Moschetti W.E. Long-term implant survivorship and modes of failure in simultaneous concurrent bilateral total knee arthroplasty. J Arthroplasty. 2020;35:139–144. - PMC - PubMed

LinkOut - more resources