An official website of the United States government
The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you’re on a federal
government site.
The site is secure.
The https:// ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
Potential conflicts of interest. The authors: B.Z.S reports no conflicts of interest. C.R.W reports advisory board work with Atea Pharmaceuticals, Invivyd and Janssen Pharamceuticals. Both authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
Luetkemeyer AF, Chew KW, Lacey S, Hughes MD, Harrison LJ, Daar ES, Eron J, Fletcher CV, Greninger AL, Hessinger D, Li JZ, Mailhot D, Wohl D, Chayakulkeeree M, Mendoza JLA, Elistratova P, Makinde O, Morgan G, Portsmouth S, Uehara T, Smith D, Currier JS.Luetkemeyer AF, et al.Clin Infect Dis. 2025 Jul 18;80(6):1235-1244. doi: 10.1093/cid/ciaf029.Clin Infect Dis. 2025.PMID: 39960062Free PMC article.Clinical Trial.
References
Luetkemeyer AF, Chew KW, Lacey S, et al. Ensitrelvir for the treatment of nonhospitalized adults with COVID-19: results from the SCORPIO-HR phase 3, randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2025; 80:1235–44.
-
PMC
-
PubMed
Yotsuyanagi H, Ohmagari N, Doi Y, et al. Efficacy and safety of 5-day oral ensitrelvir for patients with mild to moderate COVID-19: the SCORPIO-SR randomized clinical trial. JAMA Network Open 2024; 7:e2354991.
-
PMC
-
PubMed
Hammond J, Fountaine RJ, Yunis C, et al. Nirmatrelvir for vaccinated or unvaccinated adult outpatients with Covid-19. N Engl J Med 2024; 390:1186–95.
-
PMC
-
PubMed
Horga A, Kuritzkes DR, Kowalczyk JJ, et al. Phase II study of bemnifosbuvir in high-risk participants in a hospital setting with moderate COVID-19. Future Virol 2023; 18:489–500.
-
PMC
-
PubMed
Horga A, Saenz R, Yilmaz G, et al. Oral bemnifosbuvir (AT-527) vs placebo in patients with mild-to-moderate COVID-19 in an outpatient setting (MORNINGSKY). Future Virol 2023; doi: 10.2217/fvl-2023-0115
-
DOI
-
PMC
-
PubMed