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. 2025 Sep 12;96(10):990-997.
doi: 10.1136/jnnp-2024-334788.

Characterising alexithymia in individuals with functional motor disorders: a cross-sectional analysis of the Italian Registry of Functional Motor Disorders

Giovanni Ostuzzi  1 , Christian Geroin  2 , Chiara Gastaldon  3 , Federico Tedeschi  3 , Francesca Maria Clesi  3 , Giacomo Trevisan  3 , Giovanni Bidello  3 , Giovanni Vita  3 , Enrico Marcuzzo  4 , Angela Sandri  4 , Luigi M Romito  5 , Roberto Eleopra  5 , Lucia Tesolin  6 , Ilaria Franch  6 , Mario Zappia  7 , Alessandra Nicoletti  7 , Benedetta Demartini  8 , Veronica Nisticò  8   9 , Nicola Modugno  10 , Enrica Olivola  10 , Andrea Pilotto  11   12 , Alessandro Padovani  11   12 , Giovanni Defazio  13 , Tommaso Ercoli  14 , Martina Petracca  15 , Rosa De Micco  16 , Carlo Dallocchio  17 , Marcello Esposito  18 , Roberto Erro  19 , Eleonora Del Prete  20 , Francesco Amaddeo  3 , Corrado Barbui  3 , Michele Tinazzi  4
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Free article

Characterising alexithymia in individuals with functional motor disorders: a cross-sectional analysis of the Italian Registry of Functional Motor Disorders

Giovanni Ostuzzi et al. J Neurol Neurosurg Psychiatry. .
Free article

Abstract

Background: Alexithymia, a personality trait characterised by difficulty in identifying and expressing emotions, may contribute to the onset and clinical presentation of functional motor disorders (FMDs), although this association remains underexplored.

Methods: From the Italian Registry of FMDs, we selected individuals recruited between November 2011 and January 2023, diagnosed with FMD according to Gupta and Lang criteria and assessed for various neurological and psychological features with validated rating scales. The main statistical analysis included regression models using the Toronto Alexithymia Scale 20 items as an explanatory variable for a set of clinical measures, adjusting for sociodemographic factors and correcting for multiple testing.

Results: In a cohort of 483 individuals, 20.7% had possible alexithymia and 31.5% had definite alexithymia. Higher levels of alexithymia were strongly associated with increased severity of depression (β=0.31, p<0.001), anxiety (β=0.32, p<0.001), general psychological distress (β=-0.27, p<0.001), fatigue (β=0.05, p<0.001) and pain (β=0.32, p<0.001) and moderately associated with a slower onset of FMD (β=0.02, p=0.003). Subscale analyses revealed that difficulties identifying feelings contributed most to these associations. No significant association was observed with motor symptom severity.

Conclusions: Emotional processing difficulties of individuals with FMD and alexithymia might increase their vulnerability to mental health problems, pain and fatigue, possibly aggravating the overall prognosis. Further research is needed to elucidate the underlying mechanisms linking alexithymia to FMD and to explore the efficacy of interventions targeting emotional awareness and regulation in this population and to prevent long-term mental health burdens.

Keywords: DEPRESSION; FUNCTIONAL NEUROLOGICAL DISORDER; SCALES.

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Conflict of interest statement

Competing interests: None declared.