[Uterine and Adnexal Metastasis of Lung Adenocarcinoma: A Case Report and Literature Review]

Abstract

Primary bronchial lung cancer, commonly known as lung cancer, is one of the malignant tumors with high morbidity and mortality in the world. In recent years, the incidence of lung cancer in women has increased, and most of them are lung adenocarcinoma. Because the early symptoms of lung cancer are occult, it is often detected when matastasis has already occurred. Endometrial and cervical metastasis is extremely rare for primary lung cancer. This article retrospectively analyzed the clinicopathological data of a patient with pulmonary microcapillary subtype adenocarcinoma with uterine and adnexal metastasis, and confirmed by morphology, immunohistochemistry and molecular detection, in order to provide references for clinical management of uterine and adnexal metastasis of lung adenocarcinoma. .

Keywords: Cervix; Endometrial neoplasms; Fallopian tube; Immunohistochemistry; Lung neoplasms; Neoplasm metastasis.

图 1. 患者病灶的PET/CT影像学资料。A：全景图；B：左肺上叶舌段肿块；C：子宫肿块；D：左肺门区淋巴结转移；E：前纵隔区淋巴结转移；F：纵隔4R区淋巴结转移；G：左腋窝淋巴结转移；H：右锁骨区淋巴结转移；I：右侧髂血管淋巴结转移；J：左侧肩胛骨转移；K：胸骨转移；L：骶骨转移。

图 2. 肿瘤HE染色（×100）及免疫组化结果（EnVision, ×200）。HE染色：A：子宫内膜；B：宫颈内口；C：宫颈外口；D：输卵管；E：癌栓；F：肺部肿块穿刺；免疫组化：子宫内膜CK7（G）、TTF-1（H）、Napsin A（I）及SPB（J）阳性表达，Pax-8（K）、WT-1（L）及CDX2（M）阴性表达。