Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Feb 18;16(1):1725.
doi: 10.1038/s41467-025-56428-2.

Reply to: Should we be careful with exercise in post-exertional malaise after Long COVID?

Brent Appelman #  1   2 , Braeden T Charlton #  3   4 , Richie P Goulding  3   4 , Tom J Kerkhoff  3   4   5   6 , Ellen A Breedveld  3   4 , Wendy Noort  3   4 , Carla Offringa  3   4 , Frank W Bloemers  4   7 , Michel van Weeghel  8 , Bauke Schomakers  8 , Pedro Coelho  9   10   11 , Jelle J Posthuma  7   12 , Eleonora Aronica  11 , W Joost Wiersinga  1   2   13 , Michèle van Vugt #  14   15 , Rob C I Wüst #  16   17
Affiliations

Reply to: Should we be careful with exercise in post-exertional malaise after Long COVID?

Brent Appelman et al. Nat Commun. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare no competing interests.

References

    1. Appelman, B. et al. Muscle abnormalities worsen after post-exertional malaise in long COVID. Nat. Commun.15, 17 (2024). - PMC - PubMed
    1. Holloszy, J. O. Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J. Biol. Chem.242, 2278–2282 (1967). - PubMed
    1. Thaweethai, T. et al. Development of a definition of postacute sequelae of SARS-CoV-2 infection. JAMA329, 1934–1946 (2023). - PMC - PubMed
    1. Tryfonos, A. et al. Functional limitations and exercise intolerance in patients with post-COVID condition: a randomized crossover clinical trial. JAMA Netw. Open7, E244386 (2024). - PMC - PubMed
    1. Charlton, B. T. et al. Skeletal muscle adaptations and post-exertional malaise in long COVID. Trends Endocrinol Metab (2024). 10.1016/j.tem.2024.11.008 Epub ahead of print. - PubMed

LinkOut - more resources