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. 2025 May 27;9(10):2453-2457.
doi: 10.1182/bloodadvances.2024015712.

Assessing AML-based risk criteria in patients with accelerated/blast-phase MPN treated with less-intensive therapy

Affiliations

Assessing AML-based risk criteria in patients with accelerated/blast-phase MPN treated with less-intensive therapy

Reid Shaw et al. Blood Adv. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: A.A.P. received honoraria from AbbVie and Bristol Myers Squibb and institutional research funding from Pfizer and Kronos Bio. R.M.S. received honoraria from Bristol Myers Squibb, Kura Oncology, Gilead Sciences, Rigel, and Servier. E.C.C. received consulting fees from AbbVie and Rigel. S.G.I. received honoraria from Medical Logix (medical education) and reports serving on an advisory board with MorphoSys. R.K.R. received research funding from Incyte, Constellation, Zentalis, Stemline, and Ryyu, as well as consulting fees from Celgene-Bristol Myers Squibb, Kartos, Zentalis, Karyopharm, Dainippon, GlaxoSmithKline-Sierra, Galecto, PharmaEssentia, Incyte, CTI BioPharma, Servier, MorphoSys/Constellation, and Sumitomo. T.B. reports membership on the advisory committee for Novartis, Geron Corporation, and Gilead, as well as participation in the speakers’ bureau for Novartis. Y.A. received research funding from Biomea, Curis, BioSight, ALX Oncology Novartis; and honoraria from Servier, Pfizer, Bristol Myers Squibb, Kite, Astellas, and Rigel. J.S.G. received research funding from AbbVie, Genentech, New Wave, Pfizer, and Prelude; and served on the steering committees and scientific advisory boards of AbbVie, Bristol Myers Squibb, Genentech, and Servier. V.G. received research funding from AbbVie and Novartis; reports consulting fees from Novartis, Bristol Myers Squibb/Celgene, Keros, AbbVie, Constellation Biopharma, Pfizer, GlaxoSmithKline, and CTI BioPharma; reports honoraria from Novartis, Bristol Myers Squibb/Celgene, and AbbVie; and serves on the data safety monitoring or advisory board for Bristol Myers Squibb/Celgene, Roche, AbbVie, Pfizer, GlaxoSmithKline, and CTI BioPharma. K.M.P. reports consulting fees from Protagonist Therapeutics and AbbVie; received research funding from Protagonist Therapeutics, Merck, and AbbVie; and reports speakers bureau membership with Merck. O.O. reports receiving consulting fees from AbbVie, Blueprint Medicines, Bristol Myers Squibb, CTI, Impact Biomedicines, Kymera, Novartis, Servier, Taiho Pharmaceutical, and Treadwell Therapeutics. Additionally, funding for research (to institution) has been received from AbbVie, Agios, Aprea AB, Astex Pharmaceuticals, AstraZeneca, Bristol Myers Squibb, Celgene, CTI BioPharma Corp, Daiichi Sankyo, Incyte, Janssen Oncology, Kartos Therapeutics, Loxo, Novartis, NS Pharma, and OncoTherapy Science. The remaining authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Mutational and ELN risk profile of patients with MPN-AP/BP. (A) Oncoprint shows an integrated annotation of mutations and ELN risk categories. Patients are organized in columns with genes labeled along the rows. Bar plots illustrate the mutations per patient (top) and the frequency of mutations in the cohort (right). ELN risk classifications are color-coded (bottom). The green square marks a mutated gene. (B) The Sankey plot displays the changes in risk assignment across the 2017, 2022, 2024, and refined 2024 ELN criteria. (C) Dot plot representation of the mutation frequency in the BEAT AML cohort of patients and MPN AP/BP patients. Overlapping sequenced genes are depicted.
Figure 2.
Figure 2.
OS and multivariate analysis. Kaplan-Meier OS curves for (A) ELN 2017, (B) ELN 2022, (C) ELN 2024, and (D) refined ELN 2024 risk criteria. The global P value is shown. A vertical tick mark indicates censoring. (E) Forest plot summarizing the results from a multivariate Cox proportional hazards model adjusted for genes mutated at a frequency >5%. The hazard ratio (HR) is represented as a blue square, while the 95% CI is displayed as a horizontal line. An HR of <1 indicates that mutated genes confer a longer OS than the reference group (wildtype). Conversely, an HR of >1 suggests a shorter OS than the reference group.

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