[p62: Intersection of Antioxidant Defense and Autophagy Pathways]

Abstract

Numerous regulatory cascades link the cell response to oxidative stress and the mechanisms that maintain homeostasis and cell viability. The review summarizes the molecular mechanisms of interaction of the autophagy protein p62 with cell defense systems, primarily through the NRF2/KEAP1/ARE pathway. Understanding the cross-regulation of antioxidant defense and autophagy pathways contributes to the search for promising molecular targets to prevent and treat age-related diseases.

Keywords: KEAP1; NRF2; aging; autophagy; p62; regulatory loop; sestrins.