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. 2025 Apr 2:51:126886.
doi: 10.1016/j.vaccine.2025.126886. Epub 2025 Feb 18.

A population-based measles serosurvey in Mexico: Implications for re-emergence

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A population-based measles serosurvey in Mexico: Implications for re-emergence

Martha Carnalla et al. Vaccine. .
Free article

Abstract

Background: Measles is a highly contagious, potentially life-threatening viral disease targeted for global elimination. Deficiencies in vaccination programs and vaccine-induced immunity waning may favor re-emergence. In 2020, Mexico experienced an outbreak, mainly affecting adults in urban areas.

Methods: To estimate vaccination-induced serostatus, we used a probabilistic population-based sample of individuals from the ENSANUT survey in 2022. Seroprevalence was estimated by plaque reduction neutralization test (PRNT) and anti-measles IgG ELISA.

Results: Seroprevalence was 82.4 % (95 %CI 79.6, 85.0 %) by PRNT and 61.1 % (95 %CI 58.6, 63.7 %) by ELISA. The 20-29 years of age group showed the lowest PRNT seroprevalence (63.6 %), followed by the 30-39 group (71.8 %) and 40-49 (77.7 %).

Discussion: Low seroprevalence in young adults suggests possible low coverage of the second dose and/or waning immunity in absence of viral circulation in the 1989-2008 birth cohorts. In case of imported introduction of measles cases, susceptibility in young adults and adults could facilitate an outbreak.

Keywords: Health surveys; Immunity; MMR vaccine; Measles; Seroprevalence.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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