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Case Reports
. 2025 Sep 1;64(17):2587-2591.
doi: 10.2169/internalmedicine.4552-24. Epub 2025 Feb 18.

Significance of an Early Diagnosis of Autoimmune Gastritis in Nonelderly Patients with Type 1 Diabetes Mellitus and Autoimmune Thyroid Disease

Tomoya Katayama  1   2 , Naoko Nakanishi  2 , Hiroyuki Inagake  1 , Emiko Wada  1 , Aya Kitae  1 , Naoto Nakamura  1 , Michiaki Fukui  2
Affiliations
Case Reports

Significance of an Early Diagnosis of Autoimmune Gastritis in Nonelderly Patients with Type 1 Diabetes Mellitus and Autoimmune Thyroid Disease

Tomoya Katayama et al. Intern Med. .

Abstract

A 45-year-old woman with Basedow's disease, who was later diagnosed with slowly progressive type 1 diabetes mellitus (SPIDDM), developed iron deficiency anemia. Despite normal vitamin B12 levels, the endoscopic findings of the residual fundic glands and severe atrophy predominantly in the body of the stomach and fundus, along with serological tests, confirmed a diagnosis of autoimmune gastritis (AIG). This case highlights the significance of an early AIG diagnosis in non-elderly patients with type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease (AITD) because of the risk of developing pernicious anemia and gastric neoplasms.

Keywords: Basedow's (Graves) disease; autoimmune gastritis (AIG); autoimmune polyglandular syndrome (APS) type 3; latent autoimmune diabetes in adults (LADA); slowly progressive type 1 diabetes mellitus (SPIDDM); thyrogastric disease.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure.
Figure.
Esophagogastroduodenoscopy. (A) Antrum, (B) Body, (C) Upper part of body to the cardia. Photographed by Tomoya Katayama.
See this image and copyright information in PMC

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