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Case Reports
. 2025 Feb;53(2):3000605251318204.
doi: 10.1177/03000605251318204.

Visceral leishmaniasis related secondary haemophagocytic syndrome: A case report

Chen Chen  1 , Yankun Yu  2 , Long Zhen Zhu Ma  1 , Jing Nin  1 , Daqian Zhang  1 , Weixia Nong  1 , Xin Pan  1
Affiliations
Case Reports

Visceral leishmaniasis related secondary haemophagocytic syndrome: A case report

Chen Chen et al. J Int Med Res. 2025 Feb.

Abstract

Visceral leishmaniasis (VL) is a parasitic disease that can trigger haemophagocytic syndrome (HPS), making its prompt diagnosis crucial. The application of metagenome next-generation sequencing (mNGS) provides a rapid diagnostic approach, particularly for patients with negative bone marrow aspiration results. We present here, a case of a male patient in his early 50s who presented with fever and abdominal pain. Routine examinations failed to identify its specific cause. However, diagnosis through mNGS helped prevent a potentially fatal outcome.

Keywords: Visceral leishmaniasis; haemophagocytic syndrome; metagenome next-generation sequencing.

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Conflict of interest statement

Declaration of conflicting interestsThe authors declare there are no conflicts of interest.

Figures

Figure 1.
Figure 1.
Leishmania donovani genome coverage map (coverage rate 0.06%).
See this image and copyright information in PMC

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