Channels out of Order: A Review of Central and Peripheral Nervous System Channelopathies

Abstract

A vast range of neurological conditions impacting the central and peripheral nervous system are caused by ion channel dysfunctions, which are collectively referred to as channelopathies. These disorders, which are frequently autoimmune or genetic in nature, present as a variety of clinical syndromes, such as migraine, epilepsy, ataxia, neuropathic pain, and intermittent paralysis. The pathogenic mechanisms underlying these illnesses have been uncovered by recent developments in molecular genetics and electrophysiological research, opening up new avenues for accurate diagnosis and specialized treatment approaches. With an emphasis on important genetic variations and clinical manifestations, this study offers a targeted synthesis of channelopathies of the central and peripheral nervous system. By providing the most recent information on these complex disorders, this review aims to help physicians identify and treat channelopathies.

Keywords: central nervous system; channelopathies; ion channels; peripheral nervous system; transmembrane glycoproteins.