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Editorial
. 2025 Jan 31;14(1):7-10.
doi: 10.21037/tcr-24-1952. Epub 2025 Jan 16.

Small cell lung carcinoma with YAP1 expression and SMARCA4-deficient undifferentiated tumors

Affiliations
Editorial

Small cell lung carcinoma with YAP1 expression and SMARCA4-deficient undifferentiated tumors

Takuo Hayashi. Transl Cancer Res. .
No abstract available

Keywords: SMARCA4; SMARCA4-deficient undifferentiated tumors (SMARCA4-UT); Small cell carcinoma; YAP-1.

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Conflict of interest statement

Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-24-1952/coif). The author has no conflicts of interest to declare.

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References

    1. Gay CM, Stewart CA, Park EM, et al. Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell 2021;39:346-360.e7. 10.1016/j.ccell.2020.12.014 - DOI - PMC - PubMed
    1. Rudin CM, Durinck S, Stawiski EW, et al. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet 2012;44:1111-6. 10.1038/ng.2405 - DOI - PMC - PubMed
    1. Baine MK, Hsieh MS, Lai WV, et al. SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization. J Thorac Oncol 2020;15:1823-35. 10.1016/j.jtho.2020.09.009 - DOI - PMC - PubMed
    1. Ng J, Cai L, Girard L, et al. Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies. Clin Cancer Res 2024;30:1846-58. 10.1158/1078-0432.CCR-23-2360 - DOI - PMC - PubMed
    1. Nicholson AG, Tsao MS, Beasley MB, et al. The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015. J Thorac Oncol 2022;17:362-87. 10.1016/j.jtho.2021.11.003 - DOI - PubMed