Progressive brain atrophy during normal aging in man: a quantitative computerized tomography study
- PMID: 3997488
Progressive brain atrophy during normal aging in man: a quantitative computerized tomography study
Abstract
We quantitatively evaluated the computerized tomograms (CT) of 148 neurologically intact subjects, aged 28 to 84 years, to examine the effect of normal aging on the integrity of brain mass. Ten parameters were measured in each CT scan as indices for brain volume, including size of lateral, third and fourth ventricles, width of the sylvian and interhemispheric fissures, cortical sulci and the prepontine cistern. Most of these measurements showed that advancing age is associated with progressive loss of brain substance. Data show that the atrophy of brain during normal aging is both cortical and central and is not limited to the older population, but begins at a young age. These normative measurements may serve for comparison with data obtained from CT scans of patients with various neurological disorders.
Similar articles
-
The assessment of changes in brain volume using combined linear measurements. A CT-scan study.Neuroradiology. 1984;26(1):21-4. doi: 10.1007/BF00328197. Neuroradiology. 1984. PMID: 6738838
-
Features of brain atrophy in Parkinson's disease. A CT scan study.Neuroradiology. 1985;27(2):158-60. doi: 10.1007/BF00343788. Neuroradiology. 1985. PMID: 3990948
-
Cortical and central atrophy in chronic schizophrenia. A controlled study.Acta Psychiatr Scand. 1982 Jan;65(1):29-34. doi: 10.1111/j.1600-0447.1982.tb00818.x. Acta Psychiatr Scand. 1982. PMID: 7187173
-
Radiologic changes of the aging brain and skull.AJR Am J Roentgenol. 1984 Aug;143(2):383-9. doi: 10.2214/ajr.143.2.383. AJR Am J Roentgenol. 1984. PMID: 6377860 Review.
-
Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect.Am J Psychiatry. 1988 Feb;145(2):154-63. doi: 10.1176/ajp.145.2.154. Am J Psychiatry. 1988. PMID: 3277448 Review.
Cited by
-
Computed tomography in severe protein energy malnutrition.Arch Dis Child. 1987 Jun;62(6):589-92. doi: 10.1136/adc.62.6.589. Arch Dis Child. 1987. PMID: 3619475 Free PMC article.
-
Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2845-9. doi: 10.1073/pnas.88.7.2845. Proc Natl Acad Sci U S A. 1991. PMID: 2011592 Free PMC article.
-
Neurofilaments: The C-Reactive Protein of Neurology.Brain Sci. 2020 Jan 18;10(1):56. doi: 10.3390/brainsci10010056. Brain Sci. 2020. PMID: 31963750 Free PMC article. Review.
-
A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex.Neuroinformatics. 2012 Jan;10(1):81-96. doi: 10.1007/s12021-011-9127-9. Neuroinformatics. 2012. PMID: 21698393 Free PMC article.
-
Brain Morphometry and Cognitive Performance in Normal Brain Aging: Age- and Sex-Related Structural and Functional Changes.Front Aging Neurosci. 2022 Jan 26;13:713680. doi: 10.3389/fnagi.2021.713680. eCollection 2021. Front Aging Neurosci. 2022. PMID: 35153713 Free PMC article.