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[Preprint]. 2025 Jan 30:rs.3.rs-5913656.
doi: 10.21203/rs.3.rs-5913656/v1.

The Association of Neighborhood-Level Deprivation with Glioblastoma Outcomes: A Single Center Cohort Study

Yifei Sun  1 , Dagoberto Estevez-Ordonez  1 , Travis J Atchley  1 , Burt Nabors  1 , James Markert  1
Affiliations

The Association of Neighborhood-Level Deprivation with Glioblastoma Outcomes: A Single Center Cohort Study

Yifei Sun et al. Res Sq. .

Update in

Abstract

Purpose: Glioblastoma is the most common primary brain malignancy. Though literature has suggested the association of glioblastoma outcomes and socioeconomic status, there is limited evidence regarding the association of neighborhood-level socioeconomic deprivation on glioblastoma outcomes. The aim of this study was to assess the impact of neighborhood-level socioeconomic deprivation on glioblastoma survival.

Methods: We retrospectively reviewed all adult glioblastoma patients seen at a single institution from 2008 to 2023. Neighborhood deprivation was assessed via Area Deprivation Index (ADI), with higher ADI indicating greater neighborhood socioeconomic deprivation. Log-rank tests and multivariate cox regression was used to assess the effect of ADI and other socioeconomic variables while controlling for a priori selected clinical variables with known relevance to survival.

Results: In total, 1464 patients met inclusion criteria. The average age at diagnosis was 60 ± 14 years with a median overall survival of 13.8 months (IQR 13-14.8). The median ADI of the cohort was 66(IQR 46-84). Patients with high ADI had worse overall survival compared to patients with low ADI (11.7 vs 14.8 months, p=.001). In the multivariable model, patients with high ADI had worse overall survival (HR 1.25, 95%CI 1.09-1.43). To account for changes in WHO guidelines, we implemented the model on patients diagnosed between 2017-2023 and findings were consistent (HR 1.26,95%CI 1.01-1.56).

Conclusion: We report the first study demonstrating glioblastoma patients with higher neighborhood deprivation have worse survival after controlling for other socioeconomic and biomolecular markers. Neighborhood socioeconomic status may be a prognostic marker for glioblastoma survival.

Keywords: Area deprivation; Glioblastoma; neighborhood socioeconomic status; survival.

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Conflict of interest statement

Declarations Disclosures: The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article. Additional Declarations: No competing interests reported.

Figures

Figure 1
Figure 1
Kaplan Meier Survival Plot stratified by ADI
Figure 2
Figure 2
Forest Plot of Multivariate Cox Regression Analysis for Overall Survival A.Imputed cohort B. Complete Case cohort C. Post-2016 WHO guidelines cohort
See this image and copyright information in PMC

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