Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Mar 1;26(3):131-142.
doi: 10.2459/JCM.0000000000001703. Epub 2025 Jan 27.

Cardioneuroablation: a new treatment for vasovagal syncope

Andrea Saglietto  1   2   3 , Giulio Falasconi  3   4 , Diego Penela  3   5 , Pietro Francia  3   6 , Daniel Viveros  3 , Antonio Berruezo  3 , Vincenzo Russo  7 , Michele Brignole  8 , Tolga Aksu  9 , Matteo Anselmino  1   2 , Gaetano Maria De Ferrari  1   2 , Veronica Dusi  1   2
Affiliations
Review

Cardioneuroablation: a new treatment for vasovagal syncope

Andrea Saglietto et al. J Cardiovasc Med (Hagerstown). .

Abstract

Cardioneuroablation (CNA) is emerging as an appealing therapeutic option for patients with vasovagal reflex syncope. This review examines key aspects of CNA, including patient selection, procedural aspects and mid-term effects. We critically evaluate procedural results from recent studies and address ongoing challenges, such as the need for standardized procedural protocols and harmonized postprocedural data collection. In addition, we outline current gaps in knowledge concerning long-term pathophysiological effects of the procedure, in particular regarding ventricular arrhythmia susceptibility and exercise capacity.

PubMed Disclaimer

References

    1. Sutton R, Petersen MEV. The clinical spectrum of neurocardiogenic syncope. J Cardiovasc Electrophysiol 1995; 6:569–576.
    1. Salari N, Karimi Z, Hemmati M, Mohammadi A, Shohaimi S, Mohammadi M. Global prevalence of vasovagal syncope: a systematic review and meta-analysis. Glob Epidemiol 2024; 7:100136.
    1. Barón-Esquivias G, Gómez S, Aguilera A, et al. Short-term evolution of vasovagal syncope: influence on the quality of life. Int J Cardiol 2005; 102:315–319.
    1. Russo V, Tariq M, Parente E, et al. Prevalence and clinical predictors of vasodepressor syncope during head up tilt test. Eur J Intern Med 2024; 130:118–122.
    1. Russo V, Parente E, Comune A, et al. The clinical presentation of syncope influences the head-up tilt test responses. Eur J Intern Med 2023; 110:41–47.

LinkOut - more resources