Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Mar;32(3):e70013.
doi: 10.1111/jvh.70013.

Bocavirus Infection as a Potential Trigger for Hepatic Injury in Children

Bera Enes Seyrek  1 , Kubra Aykac  2 , İncinur Saltık Temizel  3 , Ali Bülent Cengiz  2 , Yasemin Ozsurekci  2
Affiliations
Case Reports

Bocavirus Infection as a Potential Trigger for Hepatic Injury in Children

Bera Enes Seyrek et al. J Viral Hepat. 2025 Mar.

Abstract

Human Bocavirus (HBoV) is an emerging pathogen linked to respiratory and gastrointestinal infections in children. While its role in respiratory diseases is established, its association with liver dysfunction remains unclear. This study presents six paediatric cases of elevated liver enzymes or acute liver failure during HBoV infection, including severe outcomes such as liver transplantation and one fatality. Frequent co-infections with other pathogens were noted, complicating the clinical course. Although direct evidence of HBoV's role in liver involvement is lacking, its potential contribution warrants further investigation to guide clinical management.

Keywords: bocavirus; hepatitis; pediatrics.

PubMed Disclaimer

References

    1. O. Schildgen, A. Muller, T. Allander, et al., “Human Bocavirus: Passenger or Pathogen in Acute Respiratory Tract Infections?,” Clinical Microbiology Reviews 21 (2008): 291–304.
    1. T. Ursiç and M. Petrovec, “Chapter 15 ‐ Human Bocavirus,” in Emerging Infectious Diseases, ed. O. Ergönül, F. Can, L. Madoff, and M. Akova (Academic Press, 2014), 191–201.
    1. Z. Haytoğlu and O. Canan, “Bocavirus Viremia and Hepatitis in an Immunocompetent Child,” Balkan Medical Journal 34, no. 3 (2017): 281–283.
    1. L. Kainulainen, M. Waris, M. Söderlund‐Venermo, T. Allander, K. Hedman, and O. Ruuskanen, “Hepatitis and Human Bocavirus Primary Infection in a Child With T‐Cell Deficiency,” Journal of Clinical Microbiology 46, no. 12 (2008): 4104–4105.
    1. E. G. Giannini, R. Testa, and V. Savarino, “Liver Enzyme Alteration: A Guide for Clinicians,” CMAJ 172, no. 3 (2005): 367–379, https://doi.org/10.1503/cmaj.1040752.

Publication types

LinkOut - more resources