Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 5;222(5):e20241019.
doi: 10.1084/jem.20241019. Epub 2025 Feb 20.

KLF2 expression in IgG plasma cells at their induction site regulates the migration program

Affiliations

KLF2 expression in IgG plasma cells at their induction site regulates the migration program

Wataru Ise et al. J Exp Med. .

Abstract

Newly generated plasma cells in secondary lymphoid organs migrate to niches in the bone marrow, wherein they survive as long-lived plasma cells (LLPCs). Although LLPCs have been extensively characterized, it is still unclear what the key determinant(s) are for plasma cell longevity. One model postulates that plasma cell heterogeneity is established at the induction site, thereby instructing their longevity. Here, we found that, among newly generated IgG plasma cells, integrin β7hi marks plasma cells predisposed to home to the bone marrow, whereas integrin β7lo cells remain in secondary lymphoid organs. Mechanistically, this egress-prone fraction had a higher expression of the KLF2 transcription factor, the loss of which resulted in defective egress by downregulating S1PR1 and CD11b. Disruption of plasma cell egress results in defective antibody durability, thereby making mice more susceptible to influenza reinfection. Thus, the migration program of plasma cells established at the induction site plays a critical role in determining antibody durability.

PubMed Disclaimer

Conflict of interest statement

Disclosures: The authors declare no competing interests exist.

References

    1. Ahn, G.-O., Tseng D., Liao C.-H., Dorie M.J., Czechowicz A., and Brown J.M.. 2010. Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Proc. Natl. Acad. Sci. USA. 107:8363–8368. 10.1073/pnas.0911378107 - DOI - PMC - PubMed
    1. Allen, D., Simon T., Sablitzky F., Rajewsky K., and Cumano A.. 1988. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J. 7:1995–2001. 10.1002/j.1460-2075.1988.tb03038.x - DOI - PMC - PubMed
    1. Allende, M.L., Yamashita T., and Proia R.L.. 2003. G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 102:3665–3667. 10.1182/blood-2003-02-0460 - DOI - PubMed
    1. Angeletti, D., Gibbs J.S., Angel M., Kosik I., Hickman H.D., Frank G.M., Das S.R., Wheatley A.K., Prabhakaran M., Leggat D.J., et al. . 2017. Defining B cell immunodominance to viruses. Nat. Immunol. 18:456–463. 10.1038/ni.3680 - DOI - PMC - PubMed
    1. Arnon, T.I., Horton R.M., Grigorova I.L., and Cyster J.G.. 2013. Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature. 493:684–688. 10.1038/nature11738 - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources