Analysis of gut microbiota variations in patients with Henoch-Schönlein purpura: a comprehensive systematic review

Khaled Saad^#¹, Muhammad Abd-Ellatif^#², Nehal E Abdel-Hakem³, Abdelrahman Ali⁴, Osama Ahmed Khalil⁵, Tasbih Emad⁶, Omar Abo-Gazia⁷, Asmaa Eldamaty⁸, Yusof M Omar⁹, Mohammad Alzu'bi¹⁰, Mohammad Bazzazeh¹¹, Ahmed Afifi¹², Amira H El-Ashry¹³, Sherin A Taha¹⁴, Hoda Atef Abdelsattar Ibrahim¹⁵, Thamer Alruwaili¹⁶, Amira Elhoufey^{17

18}, Hamad Ghaleb Dailah¹⁹, Anas Elgenidy⁸

Affiliations

¹ Pediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt. Khaled.ali@med.au.edu.eg.
² Faculty of Pharmacy, Al Azhar University, Assiut, Egypt.
³ Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, Egypt.
⁴ Faculty of Medicine, Minia University, Minia, Egypt.
⁵ Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
⁶ Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
⁷ Faculty of Medicine, Al-Azhar University, New Damietta Branch, Damietta, Egypt.
⁸ Faculty of Medicine, Cairo University, Cairo, Egypt.
⁹ Faculty of Medicine, Mansoura University, Mansoura, Egypt.
¹⁰ Faculty of Medicine, Hashemite University, Zarqa, Jordan.
¹¹ Faculty of Medicine, Alexandria University, Alexandria, Egypt.
¹² University of Texas MD Anderson Cancer Center, Houston, USA.
¹³ Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
¹⁴ Pediatric Department, Faculty of Medicine, Suez University, Suez, Egypt.
¹⁵ Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
¹⁶ Department of Pediatrics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
¹⁷ Department of Community Health Nursing, Alddrab University College, Jazan University, 45142, Jazan, Saudi Arabia.
¹⁸ Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.
¹⁹ Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia.

^# Contributed equally.

PMID: 39976893
DOI: 10.1007/s11255-025-04406-4

Analysis of gut microbiota variations in patients with Henoch-Schönlein purpura: a comprehensive systematic review

Khaled Saad et al. Int Urol Nephrol. 2025 Jul.

. 2025 Jul;57(7):2195-2208.

doi: 10.1007/s11255-025-04406-4. Epub 2025 Feb 20.

Authors

Affiliations

¹ Pediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt. Khaled.ali@med.au.edu.eg.
² Faculty of Pharmacy, Al Azhar University, Assiut, Egypt.
³ Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Sadat City, Egypt.
⁴ Faculty of Medicine, Minia University, Minia, Egypt.
⁵ Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
⁶ Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
⁷ Faculty of Medicine, Al-Azhar University, New Damietta Branch, Damietta, Egypt.
⁸ Faculty of Medicine, Cairo University, Cairo, Egypt.
⁹ Faculty of Medicine, Mansoura University, Mansoura, Egypt.
¹⁰ Faculty of Medicine, Hashemite University, Zarqa, Jordan.
¹¹ Faculty of Medicine, Alexandria University, Alexandria, Egypt.
¹² University of Texas MD Anderson Cancer Center, Houston, USA.
¹³ Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
¹⁴ Pediatric Department, Faculty of Medicine, Suez University, Suez, Egypt.
¹⁵ Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
¹⁶ Department of Pediatrics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
¹⁷ Department of Community Health Nursing, Alddrab University College, Jazan University, 45142, Jazan, Saudi Arabia.
¹⁸ Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.
¹⁹ Research and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia.

^# Contributed equally.

PMID: 39976893
DOI: 10.1007/s11255-025-04406-4

Abstract

Objective: The primary purpose of our study was to perform a comprehensive systematic review, aiming to bring out the association between gut microbiota, Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.

Methods: A systematic review was performed using five electronic databases, including Medline (through PubMed), Scopus, Embase, Cochrane, and Web of Science, from inspection up to March 21, 2024, to detect the studies that assessed the gut microbiota variation in Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.

Results: Microbial diversity, richness, and composition in HSP patients are decreased compared to the healthy control group. In addition, HSP patients display a different microbiota structure and show a significant difference in taxonomic abundance between HSP and health control, which differs from one level to another. At the phylum level, Bacteroidetes, Fusobacteria, and Blastocladiomycota were more abundant; at the class level, Bacteroidetes were more abundant; at the order level, Bacteroidetes were more abundant in the HSP group-stage and site of HSP involvement effect on microbiota. Gastrointestinal tract involvement is characterized by increased abundance of Streptococcus and Fusobacteria and a decrease in Faecalibacterium. Kidney involvement is characterized by increased abundance of Streptococcus spp, which can be used as an indicator of disease severity. Escherichia-Shigella can be used as a diagnostic for the recurrence of HSP because its abundance is higher than primary HSP.

Conclusion: Gut microbiota can be utilized to assess the severity, recurrence, and site of HSP infection by analyzing the diversity, richness, and abundance of specific microorganisms associated with the condition.

Keywords: Gut microbiota; Henoch–Schönlein nephritis; Henoch–Schönlein purpura.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable.

Comment in

Methodological considerations in gut microbiota research on IgA vasculitis: terminology, data presentation, and evidence limitations.
Pang S, Yu S, Zhang J. Pang S, et al. Int Urol Nephrol. 2025 Aug 20. doi: 10.1007/s11255-025-04753-2. Online ahead of print. Int Urol Nephrol. 2025. PMID: 40833490 No abstract available.

References

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1. Delbet JD et al (2017) Clinical outcomes in children with Henoch-Schönlein purpura nephritis without crescents. Pediatr Nephrol 32:1193–1199 - PubMed

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Analysis of gut microbiota variations in patients with Henoch-Schönlein purpura: a comprehensive systematic review

Affiliations

Analysis of gut microbiota variations in patients with Henoch-Schönlein purpura: a comprehensive systematic review

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

References

References:

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Miscellaneous