Acoustic holography in biomedical applications

Abstract

Acoustic holography can be used to construct an arbitrary wavefront at a desired 2D plane or 3D volume by beam shaping an emitted field and is a relatively new technique in the field of biomedical applications. Acoustic holography was first theorized in 1985 following Gabor's work in creating optical holograms in the 1940s. Recent developments in 3D printing have led to an easier and faster way to manufacture monolithic acoustic holographic lenses that can be attached to single-element transducers. As ultrasound passes through the lens material, a phase shift is applied to the waves, causing an interference pattern at the 2D image plane or 3D volume, which forms the desired pressure field. This technology has many applications already in use and has become of increasing interest for the biomedical community, particularly for treating regions that are notoriously difficult to operate on, such as the brain. Acoustic holograms could provide a non-invasive, precise, and patient specific way to deliver drugs, induce hyperthermia, or create tissue cell patterns. However, there are still limitations in acoustic holography, such as the difficulties in creating 3D holograms and the passivity of monolithic lenses. This review aims to outline the biomedical applications of acoustic holograms reported to date and discuss their current limitations and the future work that is needed for them to reach their full potential in the biomedical community.

Keywords: acoustic holograms; cavitation; cell patterning; hyperthermia; particle manipulation; ultrasound.