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Comparative Study
. 1985 May 25;260(10):6404-9.

c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts

A Srivastava, J S Norris, R J Shmookler Reis, S Goldstein
  • PMID: 3997829
Free article
Comparative Study

c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts

A Srivastava et al. J Biol Chem. .
Free article

Abstract

The cellular proto-oncogene c-Ha-ras-1 undergoes up to 4-fold amplification during the limited replicative life span of normal human diploid fibroblasts in vitro. Levels of c-Ha-ras-1 messenger RNA and its p21 protein product are correspondingly elevated. Cellular proto-oncogene amplification and overexpression, although frequently associated with tumorigenesis, may thus occur during normal cellular growth.

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